[Risk factors for cutaneous wart onset in transplant recipients].
[Risk factors for cutaneous wart onset in transplant recipients].
复制标题
[移植受者皮肤疣发病的危险因素]。
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
J. Roujeau
中科院分区：
文献类型：
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作者：
C. Pruvost;D. Penso;N. Bachot;P. Lang;J. Roujeau
引言
移植受者患皮肤疣的风险更高。我们调查了它们发病的延迟和一些可能的危险因素。
患者和方法
临床数据汇总在一个标准的问题和检查表上。尖锐湿疣的诊断依据是临床依据和患者报告评估的病程。免疫抑制治疗和人类白细胞抗原分组收集自临床移植记录。精算曲线被用来评估疣的发病延迟。为了比较两组(有尖锐湿疣患者和无尖锐湿疣患者)在移植后1年和3年的相关危险因素，进行了单因素分析。
结果
在移植时，尖锐湿疣的患病率为16/100。随着免疫抑制时间的延长而增加：1年23例，3年35例，5年45例，7年54例。疣是多发的，主要局限在手上。移植后3年内无皮肤疣的移植受者接受的免疫抑制治疗强度低于有皮肤疣的组。未发现年龄、性别、人类白细胞抗原标志物、光化性角化病与尖锐湿疣发病之间的关联。
讨论
尖锐湿疣的患病率随着移植时间的延长而增加。皮肤疣通常是多发性的，有一个慢性的病程，没有自发的缓解。更密集的免疫抑制治疗会增加这种情况的发生。这项试验不能评估癌症和疣之间的联系。根据我们的研究，光化性角化病与尖锐湿疣没有关系，也没有人类白细胞抗原标志物与尖锐湿疣的关系。
INTRODUCTION
Transplant recipients are at increased risk for cutaneous warts. We have investigated the delay of their onset warts and some possible risk factors for their occurrence.
PATIENTS AND METHODS
Clinical data were summarized on a standard question and examination sheet. Warts were diagnosed on clinical grounds and course duration assessed on patients' report. Immunosuppressive therapy and HLA group were collected from clinical transplantation records. An actuarial curve was used to evaluate the delay of onset of warts. To compare associated risk factors among the two groups (patients with warts and patients without warts) at 1 year and 3 years following transplant, single variate analysis was performed.
RESULTS
At the time of transplant, the prevalence of warts was 16 p. 100. It was increased with the duration of immunosuppression: 23 p. 100 at 1 year, 35 p. 100 at 3 years, 45 p. 100 at 5 years and 54 p. 100 at 7 years. Warts were multiple and principally localized on the hands. Transplant recipients without cutaneous warts 3 years after transplant had less intensive immunosuppressive therapy than the group with cutaneous warts. No association was found between age, sex, HLA markers, actinic keratosis and wart onset.
DISCUSSION
The prevalence of warts increases with the duration of transplantation. Cutaneous warts are generally multiple and have a chronical course without spontaneous remission. More intensive immunosuppressive therapy increases their occurrence. This trial cannot evaluate the association between carcinoma and warts. On the basis of our study, there is no relationship between actinic keratosis and warts, nor HLA markers and warts.