Prognostic factors for multiple myeloma in the dog.
Prognostic factors for multiple myeloma in the dog.
复制标题
狗多发性骨髓瘤的预后因素。
DOI：
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发表时间：
1986
期刊：
影响因子：
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通讯作者：
A. Hurvitz
中科院分区：
文献类型：
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作者：
Matus Re;Leifer Ce;MacEwen Eg;A. Hurvitz
在60只狗中诊断出多发性骨髓瘤。通过骨髓穿刺检查发现浆细胞大于5%，并检测到免疫球蛋白（IG）A或IgG的单克隆丙种球蛋白病，证实了每例病例的诊断。美法仑、环磷酰胺和泼尼松治疗与长期生存相关（中位数，540天）。对治疗的反应与预后显著相关（P <0.01），而高钙血症和IG轻链蛋白尿（Bence Jones）与中位生存时间较短相关。
Multiple myeloma was diagnosed in 60 dogs. Diagnosis was confirmed in each case by observation of greater than 5% plasma cells on examination of a bone marrow aspirate and detection of monoclonal gammopathy of immunoglobulin (Ig) A or IgG. Treatment with melphalan, cyclophosphamide, and prednisone was associated with long-term survival (median, 540 days). Response to therapy was significantly related to prognosis (P less than 0.01), whereas hypercalcemia and Ig light chain proteinuria (Bence Jones) were associated with shorter median survival times.