Mixed tocopherols inhibit azoxymethane-induced aberrant crypt foci in rats
Mixed tocopherols inhibit azoxymethane-induced aberrant crypt foci in rats
复制标题
DOI：
10.1207/s15327914nc5601_11
复制
发表时间：
2006-01-01
影响因子：
2.9
通讯作者：
Reddy, Bandaru S.
中科院分区：
文献类型：
--
作者：
Newmark, Harold L.;Huang, Mou-Tuan;Reddy, Bandaru S.
伽玛（gamma）生育酚，而不是α（a）生育酚（维生素E），先前已被报道为环加氧酶（COX）酶活性的有效抑制剂。在对 17 只大鼠进行的一项初步研究中，将含有超过 50% γ-生育酚的混合生育酚以 0.1% 添加到 AIN-76A 饮食中，对氧化偶氮甲烷诱导的大鼠结肠异常隐窝病灶产生显着抑制（约 55%）。当局部使用时，混合生育酚还可以减少十四烷酰佛波醇乙酸酯引起的小鼠耳部炎症。
Gamma (gamma) tocopherol, but not alpha (a) tocopherol (vitamin E), has previously been reported as an effective inhibitor of cyclooxygenase (COX) enzyme activity. In a pilot study of 17 rats, mixed tocopherols containing more than 50% gamma-tocopherol, added at 0.1% to an AIN-76A diet, produced a significant inhibition (about 55%) of azoxy-methane-induced aberrant crypt foci in the colon of rats. Mixed tocopherols also reduced tetradecanoyl phorbol acetate-induced ear inflammation in mice when topically applied.