Stem Cell Therapy: Repurposing Cell-Based Regenerative Medicine Beyond Cell Replacement
Stem Cell Therapy: Repurposing Cell-Based Regenerative Medicine Beyond Cell Replacement
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DOI：
10.1007/5584_2018_174
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发表时间：
2018-01-01
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影响因子：
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通讯作者：
Borlongan, Cesar V.
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文献类型：
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作者：
Napoli, Eleonora;Lippert, Trenton;Borlongan, Cesar V.
干细胞表现出简单和幼稚的细胞特征，但它们用于再生医学的确切目的仍然回避甚至从发育生物学到临床治疗学的最优雅设计的研究范式。基于它们无限分裂的能力和它们动态分化成任何类型的组织，可移植干细胞的出现为衰老相关和损伤介导的疾病提供了潜在的治疗。最近的实验室证据表明，移植的人神经干细胞通过启动脑神经源性区域的多个再生过程促进内源性修复机制。在这些高度增殖的小生境中存在无数有效的再生分子，包括细胞因子、蛋白质组和神经营养因子，它们共同代表了一种生物化学鸡尾酒，对于恢复衰老和患病大脑的脑功能至关重要。在这里，我们提出了治疗性再利用干细胞的概念，而不是细胞替代本身，而是利用细胞的内在特性作为宿主脑再生催化剂。
Stem cells exhibit simple and naive cellular features, yet their exact purpose for regenerative medicine continues to elude even the most elegantly designed research paradigms from developmental biology to clinical therapeutics. Based on their capacity to divide indefinitely and their dynamic differentiation into any type of tissue, the advent of transplantable stem cells has offered a potential treatment for aging-related and injury-mediated diseases. Recent laboratory evidence has demonstrated that transplanted human neural stem cells facilitate endogenous reparative mechanisms by initiating multiple regenerative processes in the brain neurogenic areas. Within these highly proliferative niches reside a myriad of potent regenerative molecules, including antiinflammatory cytokines, proteomes, and neurotrophic factors, altogether representing a biochemical cocktail vital for restoring brain function in the aging and diseased brain. Here, we advance the concept of therapeutically repurposing stem cells not towards cell replacement per se, but rather exploiting the cells' intrinsic properties to serve as the host brain regenerative catalysts.