Phylogeny of ion channels: clues to structure and function
Phylogeny of ion channels: clues to structure and function
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DOI：
10.1016/s1096-4959(01)00376-1
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发表时间：
2001-05-01
影响因子：
2.2
通讯作者：
Greenberg, RM
中科院分区：
文献类型：
--
作者：
Anderson, PAV;Greenberg, RM
Voltage-gated ion channels are responsible for the electrical activity in a variety of cell types in modern-day animals, However, they represent the result of many millions of years of evolution of a family of ion channel proteins that are also found in prokaryotes and diverse eukaryotes, and probably exist in all life forms. This review traces the evolution of ion channels, with particular emphasis on the factors and evolutionary pathways that may have given rise to voltage-gated potassium (K+), calcium (Ca2+), and sodium (Na+) channels. The review also highlights the utility of comparing phylogenetically distinct versions of the same protein as a means to better understand the structure and function of proteins. (C) 2001 Elsevier Science Inc. All rights reserved.
