The Role of Efferocytosis in Atherosclerosis.
The Role of Efferocytosis in Atherosclerosis.
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DOI：
10.1161/circulationaha.116.025684
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发表时间：
2017-01-31
期刊：
影响因子：
37.8
通讯作者：
Leeper NJ
中科院分区：
文献类型：
--
作者：
Kojima Y;Weissman IL;Leeper NJ
长期以来，坏死的核心一直是脆弱的动脉粥样硬化斑块的标志。虽然几乎所有其他组织床上的凋亡细胞很快就被清除了，但它们在病变血管中的清除似乎受到了显著的损害。新出现的证据表明，这种现象的发生是由于“吞噬作用”的缺陷，即细胞凋亡被巨噬细胞等吞噬细胞吞噬的过程。遗传和实验数据表明，在动脉粥样硬化形成过程中，由于控制经历细胞程序性死亡的细胞的‘可食性’的所谓‘Eat Me’配体的失调，吞噬功能受到了损害。下面重点介绍的是最近数据的摘要，这些数据表明，泡泡吞噬是病变扩大的主要未被认识的驱动因素，但也是一种可逆的缺陷，可以潜在地作为预防斑块进展的一种手段。
The necrotic core has long been a hallmark of the vulnerable atherosclerotic plaque. While apoptotic cells are cleared very quickly in almost all other tissue beds, their removal appears to be significantly impaired in the diseased blood vessel. Emerging evidence indicates that this phenomenon occurs due to a defect in ‘efferocytosis’, the process by which apoptotic tissue is recognized for engulfment by phagocytic cells such as macrophages. Genetic and experimental data suggest that efferocytosis is impaired during atherogenesis due to dysregulation of so-called ‘eat me’ ligands which govern the ‘edibility’ of cells undergoing programmed cell death. Highlighted below is a summary of recent data indicating that efferocytosis is a major unappreciated driver of lesion expansion, but also a reversible defect that can potentially be targeted as a means to prevent plaque progression.