Erectile Dysfunction and Risk of Cardiovascular Disease Meta-Analysis of Prospective Cohort Studies
Erectile Dysfunction and Risk of Cardiovascular Disease Meta-Analysis of Prospective Cohort Studies
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DOI：
10.1016/j.jacc.2011.06.024
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发表时间：
2011-09-20
影响因子：
24
通讯作者：
Qin, Li-Qiang
中科院分区：
文献类型：
--
作者：
Dong, Jia-Yi;Zhang, Yong-Hong;Qin, Li-Qiang
目的通过对前瞻性队列研究进行荟萃分析，评估勃起功能障碍（艾德）与心血管疾病（CVD）风险和全因死亡率之间的关系。然而，艾德是否是一个独立的危险因素，CVD.Methods的PubMed数据库检索到2011年1月，以确定研究，满足预先规定的纳入标准。还审查了检索文章的参考文献列表。两位作者独立提取了有关研究设计、研究参与者特征、暴露和结局评估以及潜在混杂因素控制的信息。使用固定效应或随机效应模型来计算总体综合风险估计。结果荟萃分析纳入了12项前瞻性队列研究，涉及36，744名参与者。与对照组相比，男性艾德的总体综合相对风险为1.48（95%置信区间[CI]：1.25 - 1.74），CVD，1.46（95% CI：1.31 - 1.63），卒中为1.35（95% CI：1.19 - 1.54），全因死亡率为1.19（95% CI：1.05 - 1.34）。敏感性分析仅限于控制常规心血管危险因素的研究，得出了类似的结果。没有证据表明发表偏倚observed.Conclusions前瞻性队列研究的荟萃分析表明，艾德显着增加心血管疾病，冠心病，中风和全因死亡率的风险，增加可能是独立的传统的心血管危险因素。（J Am科尔心脏病学杂志2011; 58：1378-85）（C）美国心脏病学会基金会2011年
Objectives Our goal was to evaluate the association between erectile dysfunction (ED) and risk of cardiovascular disease (CVD) and all-cause mortality by conducting a meta-analysis of prospective cohort studies.Background Observational studies suggest an association between ED and the incidence of CVD. However, whether ED is an independent risk factor of CVD remains controversial.Methods The PubMed database was searched through January 2011 to identify studies that met pre-stated inclusion criteria. Reference lists of retrieved articles were also reviewed. Two authors independently extracted information on the designs of the studies, the characteristics of the study participants, exposure and outcome assessments, and control for potential confounding factors. Either a fixed-or a random-effects model was used to calculate the overall combined risk estimates.Results Twelve prospective cohort studies involving 36,744 participants were included in the meta-analysis. The overall combined relative risks for men with ED compared with the reference group were 1.48 (95% confidence interval [CI]: 1.25 to 1.74) for CVD, 1.46 (95% CI: 1.31 to 1.63) for coronary heart disease, 1.35 (95% CI: 1.19 to 1.54) for stroke, and 1.19 (95% CI: 1.05 to 1.34) for all-cause mortality. Sensitivity analysis restricted to studies with control for conventional cardiovascular risk factors yielded similar results. No evidence of publication bias was observed.Conclusions This meta-analysis of prospective cohort studies suggests that ED significantly increases the risk of CVD, coronary heart disease, stroke, and all-cause mortality, and the increase is probably independent of conventional cardiovascular risk factors. (J Am Coll Cardiol 2011; 58: 1378-85) (C) 2011 by the American College of Cardiology Foundation