The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States.
The association of family history of liver cancer with hepatocellular carcinoma: a case-control study in the United States.
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DOI：
10.1016/j.jhep.2008.08.016
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发表时间：
2009-02
影响因子：
25.7
通讯作者：
Li D
中科院分区：
文献类型：
--
作者：
Hassan MM;Spitz MR;Thomas MB;Curley SA;Patt YZ;Vauthey JN;Glover KY;Kaseb A;Lozano RD;El-Deeb AS;Nguyen NT;Wei SH;Chan W;Abbruzzese JL;Li D
该研究旨在解决美国肝癌阳性家族史与肝细胞癌（HCC）发展之间的联系。德克萨斯大学医学博士在安德森癌症中心，研究了347名经病理证实的肝癌患者和1075名健康对照。所有受试者都接受了癌症家族史的采访，包括癌症亲属的数量，癌症的类型，个人与亲属的关系，以及亲属被诊断的年龄。独立于B肝炎病毒（HBV）和丙型肝炎病毒（HCV），一级亲属的肝癌史与HCC的发生显著相关（AOR = 4.1 [95%CI，1.3-12.9]）。多个亲属患有肝癌仅见于慢性HBV/ HCV感染的HCC患者。患肝癌的同胞与HBV/HCV感染和无HBV/HCV感染的HCC发展显著相关;（AOR = 5.7 [95%CI，1.2-27.3]）和（AOR = 4.3 [95%CI，1.01-20.9]）。HBV/HCV感染和肝癌家族史的个体发生HCC的风险更高（AOR = 61.9 [95%CI，6.6-579.7]）。在美国，肝癌的一级家族史与HCC的发展相关。进一步研究探索与HCC风险相关的遗传-环境相互作用是必要的。
The study aimed at addressing the connection between positive family history of liver cancer and hepatocellular carcinoma (HCC) development in the USA. At The University of Texas M.D. Anderson Cancer Center, 347 patients with pathologically confirmed HCC and 1075 healthy controls were studied. All subjects were interviewed for their family history of cancer, including the number of relatives with cancer, the type of cancer, the individual’s relationship with the relative, and the age at which the relative was diagnosed. Independently of hepatitis B virus (HBV) and hepatitis C virus (HCV), a history of liver cancer in first degree relatives was significantly associated with HCC development (AOR = 4.1 [95% CI, 1.3–12.9]). Multiple relatives with liver cancer were only observed among HCC patients with chronic HBV/ HCV infection. Affected siblings with liver cancer is significantly associated with HCC development with and without HBV/HCV infection; (AOR = 5.7 [95% CI, 1.2–27.3]) and (AOR = 4.3 [95% CI, 1.01–20.9]), respectively. Individuals with HBV/HCV and a family history of liver cancer were at higher risk for HCC (AOR = 61.9 [95% CI, 6.6–579.7]). First degree family history of liver cancer is associated with HCC development in the USA. Further research exploring the genetic-environment interactions associated with risk of HCC is warranted.
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影响因子：
5
作者：
BRENNER, H;BLETTNER, M
通讯作者：
BLETTNER, M
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通讯作者：
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