The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects.
The perplexing paradox of paraquat: the case for host-based susceptibility and postulated neurodegenerative effects.
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DOI：
10.1002/jbt.21552
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发表时间：
2014-05
影响因子：
3.6
通讯作者：
Williams RW
中科院分区：
文献类型：
--
作者：
Jones BC;Huang X;Mailman RB;Lu L;Williams RW
百草枯是一种在农业中广泛使用的除草剂，也被认为是帕金森氏症的风险因素。到目前为止，百草枯神经毒性的实验、临床和流行病学数据都是模棱两可的。在这篇简短的综述中，我们讨论了导致百草枯神经毒性不一致的一些技术和生物学机制。我们假设，易感性的个体遗传变异会导致神经毒性风险和功能结果的重大差异。识别这些可遗传的宿主易感性变异来源及其在复杂的基因-环境相互作用中的作用，对于识别风险生物标记物，以及为暴露于百草枯和其他潜在神经毒物的人设计更好的预防和治疗至关重要。
Paraquat is an herbicide used extensively in agriculture, and has also been proposed to be a risk factor for Parkinson’s disease. To date, experimental, clinical, and epidemiological data on paraquat neurotoxicity have been equivocal. In this short review, we discuss some technical and biological mechanisms that contribute to inconsistencies regarding paraquat neurotoxicity. We hypothesize that individual genetic variations in susceptibility generate major differences in neurotoxic risk and functional outcome. Identifying these heritable sources of variation in host susceptibility, and their role in complex gene-environment interactions, is crucial to identify risk biomarkers, and to devise better prevention and treatment for those exposed to paraquat and other potential neurotoxicants.