Association between urinary angiotensinogen excretion rates and left ventricular mass index and carotid intima–media thickness in hypertensive kidney transplant recipients

Association between urinary angiotensinogen excretion rates and left ventricular mass index and carotid intima–media thickness in hypertensive kidney transplant recipients
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高血压肾移植受者尿血管紧张素原排泄率与左心室质量指数和颈动脉内膜中层厚度之间的关系

DOI:
10.1111/ctr.12521
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发表时间:
2015
影响因子:
2.1
通讯作者:
C. Usalan
C. Usalan
中科院分区:
医学3区
文献类型:
--
作者:
O. Tiryaki;C. Usalan

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肾素-血管紧张素系统(RAS)被认为是调节血压,是左心室肥厚(LVH)和颈动脉内膜中层厚度(CIMT)发展的独立危险因素。最近已经描述了大多数组织中局部产生的RAS。据报道,尿血管紧张素原水平提供了肾内RAS状态的特异性指标,并与血压和蛋白尿显著相关。本研究的目的是评估高血压肾移植受者(RTRs)局部肾内RAS与LVH和CIMT的关系。
The renin‐angiotensin system (RAS) is thought to regulate blood pressure and to be an independent risk factor for the development of left ventricular hypertrophy (LVH) and carotid intima–media thickness (CIMT). Locally produced RAS in most tissues has been recently described. It has been reported that urinary angiotensinogen levels provide a specific index of the intrarenal RAS status and is significantly correlated with blood pressure and proteinuria. The aim of this study was to evaluate the relationship of local intrarenal RAS with LVH and CIMT in hypertensive renal transplant recipients (RTRs).
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