A single mouse monoclonal antibody, E58 modulates multiple IgE epitopes on group 1 cedar pollen allergens.
A single mouse monoclonal antibody, E58 modulates multiple IgE epitopes on group 1 cedar pollen allergens.
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DOI：
10.1016/j.molimm.2016.04.006
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发表时间：
2016-06
影响因子：
3.6
通讯作者：
Midoro-Horiuti T
中科院分区：
文献类型：
--
作者：
Goldblum RM;Ning B;Judy BM;Holthauzen LM;van Bavel J;Kamijo A;Midoro-Horiuti T
我们最近描述了一个占主导地位的作用，构象表位的第1组过敏原的山雪松（杜松，柏科），六月一日，在花粉过敏在美国中南部，因为这些表位的表面暴露，并可能是灵活的，他们可能会受到分子或物理扰动。这可能使Jun a1成为雪松花粉症新疗法的潜在靶点。在这里，我们描述了一种称为E58的小鼠单克隆抗体，其结合来自世界上三个人口稠密地区（美国中部，法国和日本）。在与这些过敏原结合后，E58强烈降低患者的IgE抗体与这些主要过敏原的结合。E58的这一特性，以及潜在的其他类似抗体，表明有机会鉴定可以抑制雪松花粉致敏或预防过敏反应的预防或治疗剂。
We recently described a dominant role for conformational epitopes on the group 1 allergen of the mountain cedar (Juniperus ashei, Cupressaceae), Jun a 1, in pollen hypersensitivity in South Central U.S.A. Since these epitopes are surface exposed and are likely to be flexible, they may be susceptible to molecular or physical perturbations. This may make Jun a 1 a potential target for new forms of therapy for cedar pollinosis. Here, we describe a mouse monoclonal antibody, termed E58, which binds to the group 1 allergens of cedar pollens from three highly populated regions of the world (central U.S.A., France and Japan). Upon binding to these allergens, E58 strongly reduces the binding of patient’s IgE antibodies to these dominant allergens. This characteristic of E58, and potentially other similar antibodies, suggests an opportunity to identify preventative or therapeutic agents that may inhibit cedar pollen sensitization or prevent the allergic reactions.