Serum insulin-like growth factor binding proteins (IGFBPs) as markers for anabolic/catabolic condition in fishes
Serum insulin-like growth factor binding proteins (IGFBPs) as markers for anabolic/catabolic condition in fishes
复制标题
DOI：
10.1016/s1096-4959(01)00314-1
复制
发表时间：
2001-06-01
影响因子：
2.2
通讯作者：
Galima, MM
中科院分区：
文献类型：
--
作者：
Kelley, KM;Haigwood, JT;Galima, MM
在鱼类以及所有已评估的脊椎动物中，向catabolic的生理转变（例如在食物剥夺期间）始终与至少一种（鱼类中通常为两种）小于或等于31 kDa大小范围的IGFBP血清水平升高相关。在哺乳动物中，30-kDa IGFBP-1在分解代谢情况下被强烈上调，并且它通过螯合IGF肽来抑制能量昂贵的生长直到条件更有利（例如，恢复进食）而发挥重要的生理作用。同样，在鱼类中，已经发现，当小于或等于31-kDa的IGFBP在血清中升高时，体细胞生长受到抑制，表明这些蛋白质具有与哺乳动物IGFBP-1类似的生长抑制作用。本文比较了三种不同的实验诱导的鱼类分解代谢状态：禁食、胰岛素依赖型糖尿病（IDDM）和应激。在每种情况下，血清皮质醇浓度升高和IGFBPs的存在之间的强有力的关系被注意到，血清IGFBP测量作为一个有效的指标（标记）在鱼类的分解代谢条件的效用进行了讨论。(C)2001 Elsevier Science Inc. All rights reserved.
In fishes as well as in all Vertebrates in which it has been assessed, physiological shifts toward catabolism (e.g. uch as during food deprivation) are consistently associated with elevations in the serum levels of at least one (often two in fishes) IGFBP in the less than or equal to 31-kDa size range. In mammals, 30-kDa IGFBP-1 is strongly up-regulated under catabolic circumstances, and it plays an important physiological role by sequestering IGF peptides to inhibit energy-expensive growth until conditions are more favorable (e.g, with resumed feeding). Similarly in fishes, it has been found that when the less than or equal to 31-kDa IGFBPs are elevated in serum, somatic growth is inhibited, suggesting a similar growth-inhibitory role of these proteins to that of mammalian IGFBP-1. Three different experimentally-induced catabolic states in fishes are compared in this paper: fasting; insulin-dependent diabetes mellitus (IDDM); and stress. A strong relationship between elevated serum cortisol concentrations and the presence of IGFBPs in each case is noted, and the utility of serum IGFBP measurement to serve as an effective indicator (marker) of catabolic condition in fishes is discussed. (C) 2001 Elsevier Science Inc. All rights reserved.