Endothelial dysfunction in the pulmonary vascular bed
Endothelial dysfunction in the pulmonary vascular bed
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DOI：
10.1097/00000441-200010000-00001
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发表时间：
2000-10-01
影响因子：
3.1
通讯作者：
Oparil, S
中科院分区：
文献类型：
--
作者：
Chen, YF;Oparil, S
肺内皮通过释放内皮源性收缩（EDCF）和舒张（EDRF）因子调节血管张力，其中包括内皮素-1、一氧化氮、前列环素和假定的内皮源性超极化因子。EDCF和EDRF生成的抑制已在许多心肺疾病状态中得到证实，例如原发性和继发性肺动脉高压、慢性阻塞性肺病、心肺转流术和充血性心力衰竭。EDCF和EDRF之间的不平衡，称为“肺内皮功能障碍”，可能导致肺部疾病的血管张力特征的改变。现就EDCF和EDRF在缺氧性肺动脉高压中的作用作一综述。
The pulmonary endothelium modulates vascular tone by the release of endothelium-derived constricting (EDCF) and relaxing (EDRF) factors, among them endothelin-1, nitric oxide, prostacyclin, and putative endothelium-derived hyperpolarizing factors. Abnormalities in EDCF and EDRF generation have been demonstrated in a number of cardiopulmonary disease states, such as primary and secondary pulmonary hypertension, chronic obstructive lung disease, cardiopulmonary bypass, and congestive heart failure. An imbalance between EDCF and EDRF, termed "pulmonary endothelial dysfunction," may contribute to the alteration in vascular tone characteristic of pulmonary disease. The following review summarizes the present knowledge of the role of EDCF and EDRF in such processes with major focus on pulmonary endothelial dysfunction in hypoxia-induced pulmonary hypertension.