Neuropeptide Y functions as a neuroproliferative factor
Neuropeptide Y functions as a neuroproliferative factor
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DOI：
10.1038/35073601
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发表时间：
2001-04-19
期刊：
影响因子：
64.8
通讯作者：
Ronnett, GV
中科院分区：
文献类型：
--
作者：
Hansel, DE;Eipper, BA;Ronnett, GV
神经肽Y（NPY）在哺乳动物生理学中具有许多功能（1-6）。在这里，我们确定的作用，促进出生后神经元前体细胞的增殖。NPY在出生后的嗅上皮中由支持细胞合成，先前提出仅在结构支持中起作用（7）。靶向缺失NPY 8的小鼠含有对照组一半的分裂嗅觉神经元前体细胞。此外，NPY缺乏的小鼠在成年后发育出的嗅觉神经元明显较少。NPY作用于多能神经元前体细胞或基底细胞，以快速和瞬时激活细胞外信号调节激酶（ERK）1/2亚组的促分裂原活化蛋白激酶。NPY Y1受体亚型似乎介导这种效应。NPY诱导神经元前体细胞增殖的能力是由蛋白激酶C（PKC）介导的，表明ERK 1/2的上游PKC依赖性激活。这些结果表明，神经肽Y可能调节神经元前体细胞的增殖在成年哺乳动物。
Neuropeptide Y (NPY) has a number of functions in mammalian physiology(1-6). Here we identify a role for NPY in promoting proliferation of postnatal neuronal precursor cells. NPY is synthesized in the postnatal olfactory epithelium by sustentacular cells, previously proposed to function only in structural support(7). Mice with a targeted deletion of NPY8 contain half as many dividing olfactory neuronal precursor cells as do controls. Furthermore, NPY-deficient mice develop significantly fewer olfactory neurons by adulthood. NPY acts on multipotent neuronal precursor or basal cells to activate rapidly and transiently the extracellular signal-regulated kinase (ERK)1/2 subgroup of mitogen-activated protein kinases. The NPY Y1 receptor subtype appears to mediate this effect. The ability of NPY to induce neuronal precursor proliferation is mediated by protein kinase C (PKC), indicating an upstream PKC-dependent activation of ERK1/2. These results indicate that NPY may regulate neuronal precursor proliferation in the adult mammal.