Immunohistochemical neuroendocrine differentiation is an independent prognostic factor in surgically resected large cell carcinoma of the lung
Immunohistochemical neuroendocrine differentiation is an independent prognostic factor in surgically resected large cell carcinoma of the lung
复制标题
DOI：
10.1016/s0169-5002(02)00181-2
复制
发表时间：
2002-11-01
期刊：
影响因子：
5.3
通讯作者：
Nagai, K
中科院分区：
文献类型：
--
作者：
Harada, M;Yokose, T;Nagai, K
神经内分泌（NE）分化在肺大细胞癌（LCC）中的临床意义尚不清楚。我们回顾了55例手术切除的肺癌，病理诊断为LCC，并对NE形态进行了组织学分析。用抗神经细胞粘附分子（NCAM）、嗜铬粒蛋白A（CGA）和突触素（SY）的抗体证实NE的分化。大细胞神经内分泌癌13例（24%），小细胞癌伴NE分化9例（16%），单纯小细胞癌33例（60%）。三组之间的总生存率无显著差异。当根据NE标记物表达的数量将55种癌分为三组时，NE大于或等于2的总生存率显着更好（P = 0.02）。多因素分析显示NE ≥ 2是生存的独立预测因子。NE标志物的数量在生存方面比组织学亚类更重要。皇冠版权所有（C）2002由爱思唯尔科学爱尔兰有限公司出版。保留所有权利。
The clinical significance of neuroendocrine (NE) differentiation is unclear in large cell carcinoma (LCC) of the lung. Fifty-five surgically resected carcinomas of the lung with an original pathologic diagnosis of LCC were reviewed histologically with special attention to NE morphology. Antibodies against neural cell adhesion molecule (NCAM), chromogranin A (CGA) and synaptophysin (SY) were used to confirm the NE differentiation. Thirteen (24%) cases were classified as large cell neuroendocrine carcinoma, 9 (16%) as LCC with NE differentiation, and 33 (60%) as pure LCC. There was no significant difference in overall survival between the three groups. When the 55 carcinomas were divided into three groups depending on the number of NE marker expression, there was significantly better overall survival in the NE greater than or equal to 2 (P = 0.02). Multivariate analysis proved NE greater than or equal to 2 was an independent predictor of survival. The number of NE markers was more important in terms of survival than histological subclassification. Crown Copyright (C) 2002 Published by Elsevier Science Ireland Ltd. All rights reserved.