The relationships between pubertal development, IGF-1 axis, and bone formation in healthy adolescents
The relationships between pubertal development, IGF-1 axis, and bone formation in healthy adolescents
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DOI：
10.1007/s00774-004-0544-9
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发表时间：
2005-01-01
影响因子：
3.3
通讯作者：
Kinik, E
中科院分区：
文献类型：
--
作者：
Kanbur, NÖ;Derman, O;Kinik, E
由于IGF-1是影响骨生长的主要因素，而骨钙素和骨特异性碱性磷酸酶都是青春期骨形成的重要标志物，因此这些标志物之间一定存在不随性别而变化的关系。本研究的目的是探讨青春期发育，IGF-1轴和骨形成之间的关系，在健康的青少年。205名健康儿童和青少年被纳入这项横断面研究。采用坦纳分类法确定青春期发育阶段。血清IGF-1水平和IGF-1/IGFBP-3的比例随着青春期阶段的推进而增加，最大平均值出现在女孩的III-IV期和男孩的IV期。男孩血清IGF-1和IGFBP-3水平与骨钙素和骨特异性碱性磷酸酶水平显著相关，而女孩则无相关性。这种性别之间的差异，以及IGF-1轴与青春期骨形成增加的关系，可以通过IGF-1/IGFBP-3比值的增加率来解释。我们得出结论，青春期骨形成率增加的时间，即青春期生长突增的时间，是由IGF-1/IGFBP-3比值的最大增加率决定的。但这一新假设需要纵向研究的支持。
As IGF-1 is the major factor that affects bone growth, and both osteocalcin and bone-specific alkaline phosphatase are important markers of bone formation during puberty, there must be a relationship between these markers that does not change according to sex. The aim of this study was to investigate the relationships between pubertal development, the IGF-1 axis, and bone formation in healthy adolescents. Two hundred and five healthy children and adolescents were included in this cross-sectional study. Tanner's classification was used to determine the pubertal developmental stage. Serum IGF-1 levels and IGF-1/IGFBP-3 ratios increased with advancing pubertal stages, and maximum mean values were found at stages III-IV in girls and at stage IV in boys. Serum IGF-1 and IGFBP-3 levels were significantly correlated with osteocalcin and bone-specific alkaline phosphatase levels in boys, but not in girls. This difference between the sexes, and the relation of the IGF-1 axis to increased bone formation during puberty in both sexes, can be explained by the rate of increase of the IGF-1/IGFBP-3 ratio. We conclude that the timing of the increased bone formation rate during puberty; that is, the timing of the pubertal growth spurt, is determined by the maximum increase rate of the IGF-1/IGFBP-3 ratio. But this new hypothesis needs to be supported by longitudinal studies.