Cerebral activation to intranasal chemosensory trigeminal stimulation
Cerebral activation to intranasal chemosensory trigeminal stimulation
复制标题
DOI：
10.1093/chemse/bjm004
复制
发表时间：
2007-05-01
期刊：
影响因子：
3.5
通讯作者：
Hummel, Thomas
中科院分区：
文献类型：
--
作者：
Boyle, Julie A.;Heinke, Michael;Hummel, Thomas
虽然已经有大量的功能性磁共振成像（FMRI）研究对嗅觉信息的处理进行了研究，但到目前为止，鼻内三叉神经系统还没有得到太多的关注。在本研究中，我们试图用二氧化碳（CO2）刺激左鼻孔或右鼻孔来描述三叉神经的相关神经。15名右撇子男性在三种情况下接受了功能磁共振成像（FMRI）测试（左鼻孔和右鼻孔分别吸入二氧化碳，右鼻孔吸入嗅兴奋剂苯基乙醇）。正如预期的那样，嗅觉激活位于眼窝前额皮质（OFC）、杏仁核和吻侧岛。对于三叉神经刺激，在“三叉神经”和“嗅觉”区域发现了激活，包括中央前回和中央后回、小脑、丘脑腹外侧、脑岛、对侧梨状皮质和OFC。左侧刺激比右侧刺激导致更强的小脑和脑干激活；与左刺激相比，右刺激导致颞上沟和OFC的激活更强。这些结果表明，三叉神经处理系统利用类似的皮层区域，但与嗅觉系统是分开的。三叉神经和嗅觉刺激的皮层激活重叠模式被认为是由于处理来自两个主要鼻内化学感觉系统的信息的密切联系。
Although numerous functional magnetic resonance imaging (FMRI) studies have been performed on the processing of olfactory information, the intranasal trigeminal system so far has not received much attention. In the present study, we sought to delineate the neural correlates of trigeminal stimulation using carbon dioxide (CO2) presented to the left or right nostril. Fifteen right-handed men underwent FMRI using single runs of 3 conditions (CO2 in the right and the left nostrils and an olfactory stimulant-phenyl ethyl alcohol-in the right nostril). As expected, olfactory activations were located in the orbitofrontal cortex (OFC), amygdala, and rostral insula. For trigeminal stimulation, activations were found in "trigeminal" and "olfactory" regions including the pre- and postcentral gyrus, the cerebellum, the ventrolateral thalamus, the insula, the contralateral piriform cortex, and the OFC. Left compared with right side stimulations resulted in stronger cerebellar and brain stem activations; right versus left stimulation resulted in stronger activations of the superior temporal sulcus and OFC. These results suggest a trigeminal processing system that taps into similar cortical regions and yet is separate from that of the olfactory system. The overlapping pattern of cortical activation for trigeminal and olfactory stimuli is assumed to be due to the intimate connections in the processing of information from the 2 major intranasal chemosensory systems.