Influence of scanning area on choroidal vascularity index measurement using optical coherence tomography
Influence of scanning area on choroidal vascularity index measurement using optical coherence tomography
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DOI：
10.1111/aos.13442
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发表时间：
2017-12-01
影响因子：
3.4
通讯作者：
Chhablani, Jay
中科院分区：
文献类型：
--
作者：
Agrawal, Rupesh;Wei, Xin;Chhablani, Jay
目的脉络膜血管指数（CVI）是近年来提出的一种评价脉络膜血管的新方法。在这项研究中，我们调查的影响，扫描面积的CVI测量使用光谱域光学相干断层扫描（SD-OCT）。MethodsSpectral-domain optical coherence tomography（SD-OCT），使用增强深度成像模式进行了30只眼，从15名正常人。比较了三个扫描区域：丁格尔中心凹扫描;中央黄斑扫描[通过早期治疗糖尿病视网膜病变研究（ETDRS）网格上的中央1000微米圆的扫描，内圈];和总黄斑立方体扫描。OCT B扫描的二值化和二值化脉络膜层的分割使用先前报告的经验证的自动化软件实现。计算脉络膜血管指数（CVI）百分比。中心凹、中心黄斑和全黄斑CVI之间的一致性程度采用组内相关系数（ICC）进行评估，并采用Bland-Altman plot.ResultsThe平均CVI在中心凹下、中心黄斑和全黄斑扫描分别为49.95 ± 4.84%、50.00 ± 4.68%和51.10 ± 4.63%。所有三项比较的组内相关系数（ICC）均大于0.8 [中心凹下与中心黄斑CVI，ICC=0.92（95% CI：0.84-0.96）;中心黄斑与总黄斑CVI，ICC=0.90（95% CI：0.82-0.96）;中心凹下与总黄斑CVI，ICC=0.92（95% CI：0.85-0.95）]。无显着差异的方差（所有p>0.05）之间注意到CVI测量从三个scanningareas.ConclusionChoroidal血管指数（CVI）测量是高度可重复的使用下凹，中央和总黄斑扫描在健康人。单个中心凹扫描脉络膜血管代表健康人群黄斑脉络膜血管的总量。
PurposeRecently, choroidal vascularity index (CVI) is proposed as a novel tool to evaluate the choroidal vasculature. In this study, we investigate the impact of scanning area on CVI measurement using spectral-domain optical coherence tomography (SD-OCT).MethodsSpectral-domain optical coherence tomography (SD-OCT) using enhanced depth imaging mode was performed in 30 eyes from 15 normal subjects. Three scanning areas were compared: dingle foveal scan; central macular scans [scan passing through central 1000 microns circle on Early Treatment Diabetic Retinopathy Study (ETDRS) grid, inner circle]; and total macular cube scans. Binarization of OCT B-scans and segmentation of the binarized choroid layer were achieved using a previously reported validated automated software. Choroidal vascularity index (CVI) percentage was calculated. Degree of agreement among foveal, central macular and total macular CVI was assessed using intraclass correlation coefficient (ICC) and was plotted using Bland-Altman plot.ResultsThe mean CVI in subfoveal, central macular and total macular scans was 49.954.84%, 50.00 +/- 4.68% and 51.10 +/- 4.63%, respectively. Intraclass correlation coefficient (ICC) was more than 0.8 for all three comparisons [subfoveal versus central macular CVI, ICC=0.92 (95% CI: 0.84-0.96); central macular versus total macular CVI, ICC=0.90 (95% CI: 0.82-0.96); subfoveal versus total macular CVI, ICC=0.92 (95% CI: 0.85-0.95)]. No significant differences in variance (all p>0.05) were noted among CVI measured from the three scanning areas.ConclusionChoroidal vascularity index (CVI) measurements were highly reproducible using subfoveal, central and total macular scans in healthy individuals. Single foveal scan choroidal vascularity represents total macular choroidal vascularity in healthy population.