VITAMIN-D SUPPLEMENTS IN PREGNANT ASIAN WOMEN - EFFECTS ON CALCIUM STATUS AND FETAL GROWTH
VITAMIN-D SUPPLEMENTS IN PREGNANT ASIAN WOMEN - EFFECTS ON CALCIUM STATUS AND FETAL GROWTH
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DOI：
10.1136/bmj.280.6216.751
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发表时间：
1980-01-01
影响因子：
105.7
通讯作者：
WINDER, SM
中科院分区：
文献类型：
--
作者：
BROOKE, OG;BROWN, IRF;WINDER, SM
在一项对亚洲孕妇补充维生素D的双盲试验中，59名孕妇在最后三个月期间服用了钙化醇(麦角钙化醇，1000IU/天)，67名对照组服用了安慰剂。这两组婴儿在母亲的年龄、身高、产次、素食主义者的数量、出生国家以及婴儿的性别和妊娠方面的分布相似。在试验开始时，治疗组和对照组的孕妇血清25-羟基维生素D(25-OHD)浓度都很低，素食者的水平明显低于非素食者。治疗组孕晚期体重增加快于对照组，足月时母婴血浆25-OHD浓度均充足，而对照组母婴血浆25-OHD和钙浓度较低，血浆碱性磷酸酶(骨同工酶)活性升高。其中5名婴儿出现症状性低钙血症。对照组中小于胎龄的婴儿几乎是对照组的两倍(29%比15%)，但两组婴儿在各向异性测量中没有显著差异。然而，对照组的婴儿颧骨较大，表明颅骨骨化受损。由于治疗组对母亲和婴儿有好处，而且没有副作用，英国的所有亚洲孕妇都应该服用维生素D补充剂。
In a double-blind trial of vitamin D supplements in pregnant Asian women calciferol (ergocalciferol, 1000 IU/day) was administered to 59 women and placebo to 67 controls during the last trimester. The two groups had similar distributions of maternal age, height, parity, number of vegetarians, countries of origin, and sex and gestation of the infants. At entry to the trial maternal serum 25-hydroxy vitamin D (25-OHD) concentrations were low in both treatment and control groups and significantly lower in vegetarians than non-vegetarians. Mothers in the treatment group gained weight faster in the last trimester than those in the control group, and at term they and their infants all had adequate plasma 25-OHD concentrations, Mothers and infants in the control group, however, had low plasma concentrations of 25-OHD and calcium and raised plasma alkaline phosphatase (bone isoenzyme) activity. Five of these infants developed symptomatic hypocalcaemia. Almost twice as many infants in the control group were small for gestational age (29% v 15%), but there were no significant differences between the two groups of infants in antropometric measurements. Infants in the control group, however, had larger fontanelles, suggesting impaired ossification of the skull. Because of the benefits to mothers and infants in the treatment group and the absence of side effects, vitamin D supplements should be given to all pregnant Asian women in the United Kingdom.