Imaging performance of A-PET: A small animal PET camera
Imaging performance of A-PET: A small animal PET camera
复制标题
DOI：
10.1109/tmi.2005.844078
复制
发表时间：
2005-07-01
影响因子：
10.6
通讯作者：
Muehllehner, G
中科院分区：
文献类型：
--
作者：
Surti, S;Karp, JS;Muehllehner, G
小动物正电子发射断层扫描（PET）成像技术的发展导致了高分辨率和高灵敏度的专用PET扫描仪的发展。动物PET扫描仪通过对小动物（如小鼠和大鼠）进行成像来实现这些目标。扫描仪使用像素化的Anger-logic探测器，用于区分2 x 2 x 10 mm(3)晶体和直径19 mm的光电倍增管。该扫描仪的环直径为19.7厘米，轴向长度为11.9厘米，仅在三维成像模式下运行，具有非常高的灵敏度。测量表明，该扫描仪设计在视场中心达到1.9毫米的空间分辨率。该扫描仪最初设计为正硅酸钆，但后来改为正硅酸镥钇，现在对于视场中心的点源，能量窗口为250-665 keV，灵敏度达到3.6%。结合迭代图像重建，以及精确的散射、随机和衰减数据校正，实现高质量图像和定量数据。这些结果是通过我们的对比恢复测量以及样本动物研究证明的。
The evolution of positron emission tomography (PET) imaging for small animals has led to the development of dedicated PET scanner designs with high resolution and sensitivity. The animal PET scanner achieves these goals for imaging small animals such as mice and rats. The scanner uses a pixelated Anger-logic detector for discriminating 2 x 2 X 10 mm(3) crystals with 19-mm-diameter photomultiplier tubes. With a 19.7-cm ring diameter, the scanner has an axial length of 11.9 cm and operates exclusively in three-dimensional imaging mode, leading to very high sensitivity. Measurements show that the scanner design achieves a spatial resolution of 1.9 mm at the center of the field-of-view. Initially designed with gadolinium orthosilicate but changed to lutetium-yttrium orthosilicate, the scanner now achieves a sensitivity of 3.6% for a point source at the center of the field-of-view with an energy window of 250-665 keV. Iterative image reconstruction, together with accurate data corrections for scatter, random, and attenuation, are incorporated to achieve high-quality images and quantitative data. These results are demonstrated through our contrast recovery measurements as well as sample animal studies.