Pretreatment with Hemoglobin-based Oxygen Carriers Protect Isolated Rat Heart from Myocardial Infarction
Pretreatment with Hemoglobin-based Oxygen Carriers Protect Isolated Rat Heart from Myocardial Infarction
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DOI：
10.3109/10731191003670541
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发表时间：
2010-01
期刊：
影响因子：
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通讯作者：
Tao Li;Jin Liu;Chengmin Yang
中科院分区：
文献类型：
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作者：
Tao Li;Jin Liu;Chengmin Yang
摘要本研究旨在探讨聚合人胎盘血红蛋白（PolyPHb）预处理对缺血/再灌注（I/R）损伤心脏的保护作用。基础灌注10分钟后，用0.1 gHb/dL PolyPHb预处理离体Sprague-Dawley大鼠心脏，并使其受到I/R损伤。与对照组相比，PolyPHb预处理可显著降低左室发展压（LVDP）、最大LVDP升高和降低速率（±dp/dt）以及左室舒张末期压（LVEDP）的升高。此外，心肌梗死和肌钙蛋白-I的释放显着减少前HBOCs组。因此，PolyPHb预处理对离体I/R心脏具有保护作用。
Abstract This study was designed to investigate whether polymerized human placenta hemoglobin (PolyPHb) pretreatment provided protection to the heart after ischemia/reperfusion (I/R) injury. After 10-min basal perfusion, isolated Sprague-Dawley rat hearts were pretreated with 0.1 gHb/dL PolyPHb and subjected to I/R injury. PolyPHb pretreatment greatly reduced the decreases in left ventricular developed pressure (LVDP), maximum LVDP increase and decrease rate (±dp/dt), and the increase in left ventricular end-diastolic pressure (LVEDP) as compared to the control group. Moreover, the myocardial infarction and troponin-I release were significantly reduced in the pre-HBOCs group. Therefore, PolyPHb pretreatment was protective to the isolated I/R heart.