Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss.
Urinary Concentrations of Phthalate Metabolites and Bisphenol A and Associations with Follicular-Phase Length, Luteal-Phase Length, Fecundability, and Early Pregnancy Loss.
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DOI：
10.1289/ehp.1408164
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发表时间：
2016-03
影响因子：
10.4
通讯作者：
Baird DD
中科院分区：
文献类型：
--
作者：
Jukic AM;Calafat AM;McConnaughey DR;Longnecker MP;Hoppin JA;Weinberg CR;Wilcox AJ;Baird DD
某些邻苯二甲酸盐和双酚A （BPA）在动物研究中显示出生殖效应，并可能影响人类排卵、受孕和流产。我们研究了这些化学物质与试图怀孕的妇女的卵泡期和黄体期长度、怀孕时间和早期妊娠丢失（最后一次月经后6周内）的关系。停止避孕的妇女每天提供第一天早晨的尿液标本，并记录长达6个月的阴道出血天数。以前对标本进行了雌激素和孕激素代谢物和人绒毛膜促性腺激素的分析。共有221名参与者贡献了706个月经周期。我们在每个月经周期间隔的三个样本中测量了11种邻苯二甲酸盐代谢物和BPA。我们使用卵泡期和黄体期长度的线性混合模型、妊娠时间的离散时间可生育模型和早期妊娠丢失的逻辑回归分析了化学物质浓度与结局之间的关联。较高浓度的邻苯二甲酸一羧基辛酯（MCOP）与较短的黄体期相关[第2实验组与第1实验组：-0.5天（95% CI: -0.9, -0.1），第3实验组与第1实验组：-0.4天（95% CI: -0.8, 0.01）， p = 0.04]。BPA也与较短的黄体期有关[第2天对第1天：-0.8天（95% CI: -1.2, -0.4），第3天对第1天：-0.4天（95% CI: -0.8, 0.02）， p = 0.001]。BPA和MCOP（或其前体）与黄体期缩短有关。月经周期特异性尿双酚a和邻苯二甲酸酯代谢物的估计与卵泡期长度、怀孕时间或早期妊娠丢失的有害改变无关，事实上，DEHP[二（2-乙基己基）邻苯二甲酸酯]代谢物{MEOHP[单（2-乙基-5-氧己基）邻苯二甲酸酯]和ΣDEHP}与减少早期妊娠丢失有关。这些发现将在未来的人体研究中得到证实。Jukic AM, Calafat AM, McConnaughey DR, Longnecker MP, Hoppin JA, Weinberg CR, Wilcox AJ, Baird DD. 2016。尿中邻苯二甲酸代谢物和双酚A浓度与卵泡期长度、黄体期长度、生育能力和早孕丢失的关系环境卫生展望124:321-328；http://dx.doi.org/10.1289/ehp.1408164
Certain phthalates and bisphenol A (BPA) show reproductive effects in animal studies and potentially affect human ovulation, conception, and pregnancy loss. We investigated these chemicals in relation to follicular- and luteal-phase lengths, time to pregnancy, and early pregnancy loss (within 6 weeks of the last menstrual period) among women attempting pregnancy. Women discontinuing contraception provided daily first-morning urine specimens and recorded days with vaginal bleeding for up to 6 months. Specimens had previously been analyzed for estrogen and progesterone metabolites and human chorionic gonadotropin. A total of 221 participants contributed 706 menstrual cycles. We measured 11 phthalate metabolites and BPA in pooled urine from three specimens spaced throughout each menstrual cycle. We analyzed associations between chemical concentrations and outcomes using linear mixed models for follicular- and luteal-phase lengths, discrete-time fecundability models for time to pregnancy, and logistic regression for early pregnancy loss. Higher concentrations of monocarboxyoctyl phthalate (MCOP) were associated with shorter luteal phase [2nd tertile vs. 1st tertile: –0.5 days (95% CI: –0.9, –0.1), 3rd vs. 1st: –0.4 days (95% CI: –0.8, 0.01), p = 0.04]. BPA was also associated with shorter luteal phase [2nd vs. 1st: –0.8 days (95% CI: –1.2, –0.4), 3rd vs. 1st: –0.4 days (95% CI: –0.8, 0.02), p = 0.001]. BPA and MCOP (or its precursors) were associated with shorter luteal phase. Menstrual cycle–specific estimates of urinary BPA and phthalate metabolites were not associated with detrimental alterations in follicular-phase length, time to pregnancy, or early pregnancy loss, and in fact, DEHP [di(2-ethylhexyl) phthalate] metabolites {MEOHP [mono(2-ethyl-5-oxohexyl) phthalate] and ΣDEHP} were associated with reduced early loss. These findings should be confirmed in future human studies. Jukic AM, Calafat AM, McConnaughey DR, Longnecker MP, Hoppin JA, Weinberg CR, Wilcox AJ, Baird DD. 2016. Urinary concentrations of phthalate metabolites and bisphenol A and associations with follicular-phase length, luteal-phase length, fecundability, and early pregnancy loss. Environ Health Perspect 124:321–328; http://dx.doi.org/10.1289/ehp.1408164