The relationship between abnormal glucose tolerance and hypertensive disorders of pregnancy in healthy nulliparous women
The relationship between abnormal glucose tolerance and hypertensive disorders of pregnancy in healthy nulliparous women
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DOI：
10.1016/s0002-9378(98)70210-8
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发表时间：
1998-10-01
影响因子：
9.8
通讯作者：
Catalano, PM
中科院分区：
文献类型：
--
作者：
Joffe, GM;Esterlitz, JR;Catalano, PM
目的：本研究的目的是确定妊娠期间糖耐量异常的健康未产妇患妊娠相关高血压或先兆子痫的风险是否增加。研究设计：对来自 5 个大学中心的 4589 名健康未产妇进行前瞻性评估，以确定补充钙是否可以预防先兆子痫。妊娠相关高血压是指舒张压两次大于或等于90毫米汞柱，每次间隔4小时至1周。妊娠相关蛋白尿是指两次间隔 4 小时至 1 周的试纸测试中蛋白尿大于或等于 1+，蛋白尿大于或等于 300 mg/24 小时，蛋白与肌酐比值大于或等于 0.35，或单次试纸测量大于或等于 2+。先兆子痫的定义是在 7 天内记录到妊娠相关高血压和妊娠相关蛋白尿。正常糖耐量是血浆葡萄糖水平
OBJECTIVE: The study's aim was to determine whether healthy nulliparous women with abnormal glucose tolerance during pregnancy are at increased risk for development of pregnancy-associated hypertension or preeclampsia.STUDY DESIGN: A series of 4589 healthy nulliparous women from 5 university centers were evaluated prospectively to determine whether calcium supplementation would prevent preeclampsia. Pregnancy-associated hypertension was a diastolic blood pressure greater than or equal to 90 mm Hg on 2 occasions 4 hours to 1 week apart. Pregnancy-associated proteinuria was proteinuria greater than or equal to 1+ by dipstick testing on 2 occasions 4 hours to 1 week apart, proteinuria;greater than or equal to 300 mg/24 h, a protein to creatinine ratio of greater than or equal to 0.35, or a single dipstick measurement of greater than or equal to 2+. Preeclampsia was defined as pregnancy-associated hypertension and pregnancy-associated proteinuria documented within 7 days of each other. Normal glucose tolerance was a plasma glucose level