Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations
Production of chemokines in respiratory syncytial virus infection with central nervous system manifestations
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DOI：
10.1007/s10156-012-0418-3
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发表时间：
2012-12-01
影响因子：
2.2
通讯作者：
Kato, Yuichi
中科院分区：
文献类型：
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作者：
Kawashima, Hisashi;Kashiwagi, Yasuyo;Kato, Yuichi
儿童呼吸道合胞病毒（RSV）感染可能与急性脑病有关。然而，细胞因子在此类患者脑脊液（CSF）中的作用仍未得到评估。在这项研究中，确定了 8 名患有神经系统并发症的 RSV 感染儿童的 17 种细胞因子谱。在一名 13 种细胞因子水平较高的患者中，认为发生了细胞因子风暴。其他患者的白介素 (IL)-6、IL-8、单核细胞趋化蛋白 (MCP)-1 和巨噬细胞炎症蛋白 (MIP)-1 β 水平也很高。这些数据表明脑脊液中的趋化因子在 RSV 感染儿童的神经并发症中发挥作用。
Respiratory syncytial virus (RSV) infection in children can be associated with acute encephalopathy. However, the roles of cytokines in the cerebrospinal fluid (CSF) of such patients remain unevaluated. In this study, a profile of 17 cytokines was determined for eight RSV-infected children with neurological complications. In one patient with high levels of 13 cytokines, a cytokine storm was considered to have occurred. Interleukin (IL)-6, IL-8, monocyte chemoattractant protein (MCP)-1, and macrophage inflammatory protein (MIP)-1 beta levels were also high in other patients. These data suggest that chemokines in CSF play roles in neurological complications in RSV-infected children.