Dosimetric comparison of pre-planned and OR-planned prostate seed brachytherapy
Dosimetric comparison of pre-planned and OR-planned prostate seed brachytherapy
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DOI：
10.1016/s0360-3016(00)00734-3
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发表时间：
2000-11-01
影响因子：
7
通讯作者：
Klein, EA
中科院分区：
文献类型：
--
作者：
Wilkinson, DA;Lee, EJ;Klein, EA
目的：比较传统两步法的剂量学（体积研究+几周后的治疗计划）与基于OR的单一程序（其中这两个步骤立即彼此相继）的比较，计算机生成的治疗计划用于两种程序中。从CT剂量体积直方图中获得了与靶区覆盖有关的几个剂量学参数。在种子植入后1天或3天制定基于评估的计划。共113例早期患者（T1C，T2A）前列腺癌用于本回顾性研究。目标分数处方剂量（144戈伊）覆盖的（前列腺），处方剂量（115戈伊）的90%，和评估计划中包含90%目标的剂量，与术前相比，基于OR的计划在统计学上都有显著改善。结论：在我们的手中，有一个小的，但显着的改善剂量覆盖的前列腺时，超声体积研究和治疗计划结合到一个单一的程序。(C)2000 Elsevier Science Inc.
Purpose: To compare the dosimetry of the traditional two step procedure (volume study + treatment planning several weeks later) with that of an OR-based single procedure in which these two steps follow one another immediately, Computer generated treatment plans were used in both procedures.Methods and Materials: Several dosimetric parameters relating to target coverage were obtained from dose volume histograms of CT-based evaluation plans developed either 1 or 3 days following seed implantation. A total of 113 patients with early stage (T1C, T2A) prostate cancer were used for this retrospective study.Results: The fraction of target (prostate) covered by the prescription dose (144 Gy), 90% of the prescription dose (115 Gy), and the dose encompassing 90% of the target in the evaluation plan were all statistically significantly improved for OR-based plans compared to pre-planned cases.Conclusion: In our hands, there is a small but significant improvement in dose coverage of the prostate when the ultrasound volume study and treatment planning are combined into a single procedure. (C) 2000 Elsevier Science Inc.