Association between acetaminophen or nonsteroidal Antiinflammatory drugs and risk of developing ovarian, breast, or colon cancer
Association between acetaminophen or nonsteroidal Antiinflammatory drugs and risk of developing ovarian, breast, or colon cancer
复制标题
DOI：
10.1592/phco.22.5.303.33189
复制
发表时间：
2002-03-01
期刊：
影响因子：
4.1
通讯作者：
Jick, H
中科院分区：
文献类型：
--
作者：
Meier, CR;Schmitz, S;Jick, H
研究目的。探讨对乙酰氨基酚（扑热息痛）或非甾体类抗炎药（NSAID）暴露与卵巢癌、乳腺癌或结肠癌风险之间的关系。回顾性病例对照研究。全科诊所。主题。483名卵巢癌妇女和1877名妇女在年龄、计算机记录的病史年数、参加的全科医生和日历上匹配，3706名乳腺癌妇女和14,155名匹配的对照组，635名结肠癌妇女和2434名匹配的对照组。在英国的全科医学研究数据库中检索首次诊断为卵巢癌、乳腺癌或结肠癌的50-89岁女性和匹配的对照组，以评估处方止痛药的暴露情况。定期服用对乙酰氨基酚（大于或等于30张处方）与乳腺癌（比值比[OR] 0.8，95%置信区间[CI] 0.7-1.0）发生风险略有降低相关，但与卵巢癌（OR 1.0，95% CI 0.6-1.5）或结肠癌（OR 1.0，95% CI 0.7-1.4）发生风险无关。定期服用NSAID与结肠癌风险降低相关（OR 0.5，95%CI 0.3-0.9），但与卵巢癌或乳腺癌风险降低无关。我们没有发现定期服用对乙酰氨基酚或NSAID的女性患卵巢癌风险降低的证据。
Study Objective. To explore the association between exposure to acetaminophen (paracetamol) or nonsteroidal antiinflammatory drugs (NSAIDs) and risk of developing ovarian, breast, or colon cancer.Design. Retrospective case-control study.Setting. General practice offices.Subjects. Four hundred eighty-three women with ovarian cancer and 1877 women matched for age, years of medical history in computer record, general practice attended, and calendar timed 3706 women with breast cancer and 14,155 matched control subjects and 635 women with colon cancer and 2434 matched control subjects.Intervention. United Kingdom-based General Practice Research Database was searched for women aged 50-89 years with a first-time diagnosis of ovarian, breast, or colon cancer and for matched controls to assess prescription analgesic exposure.Measurements and Main Results. Regular acetaminophen exposure (greater than or equal to30 prescriptions) was associated with a slightly decreased risk of developing breast (odds ratio [OR] 0.8, 95% confidence interval [CI] 0.7-1.0) but not ovarian (OR 1.0, 95% CI 0.6-1.5) or colon (OR 1.0, 95% CI 0.7-1.4) cancer. Regular NSAID exposure was associated with a reduced risk of colon (OR 0.5, 95% CI 0.3-0.9) but not ovarian or breast cancer.Conclusion. We found no evidence for a decreased ovarian cancer risk for women with regular acetaminophen or NSAID exposure.