A simulation model for compensatory plasticity in the prefrontal cortex inducing a cortico-cortical dysconnection in early brain development
A simulation model for compensatory plasticity in the prefrontal cortex inducing a cortico-cortical dysconnection in early brain development
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DOI：
10.1007/s00702-005-0403-4
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发表时间：
2006-05-01
影响因子：
3.3
通讯作者：
Teuchert-Noodt, G
中科院分区：
文献类型：
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作者：
Butz, M;Teuchert-Noodt, G
在目前的工作中，一个抽象的前额叶皮质模拟模型被用来预测正常和病理性前脑成熟过程中皮质-皮质连接模式的代偿性结构变化。该模拟网络显示了在未受干扰的兴奋性传入和受扰的兴奋性传入时，形态发生的不同典型过程。免疫组织化学研究证实了模拟结果，揭示了幼年和成年长爪沙鼠在甲基苯丙胺中毒后谷氨酸能投射纤维密度的变化规律。该模拟模型进一步允许考虑不同的饲养条件(富环境模型)，并提出了富养或贫养后同等干扰的矛盾效应，这与实验结果一致。
In the present work, an abstract prefrontal cortex simulation model is used to predict compensatory structural alterations of the cortico-cortical connectivity pattern in the normal and pathologic forebrain maturation. The simulation network shows different representative courses of morphogenesis when developing undisturbed or when suffering from disturbing excitatory afferences. The simulative results could be affirmed by an immuno-histochemical study, revealing a qualitatively comparable development of the glutamatergic projection fibre density in gerbils (Meriones unguiculatus) after juvenile and adult methamphetamine intoxication. The simulation model further allows to consider different rearing conditions (enriched-environment model), and claims contradictory effects of an equal disturbance after enriched or impoverished rearing which are in accordance with the experimental findings.