Nanomolar Detection of Hypochlorite by a Rhodamine-Based Chiral Hydrazide in Absolute Aqueous Media: Application in Tap Water Analysis with Live-Cell Imaging
Nanomolar Detection of Hypochlorite by a Rhodamine-Based Chiral Hydrazide in Absolute Aqueous Media: Application in Tap Water Analysis with Live-Cell Imaging
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DOI：
10.1021/ac500418k
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发表时间：
2014-07-01
影响因子：
7.4
通讯作者：
Abdel-Aziz, Hatem A.
中科院分区：
文献类型：
--
作者：
Goswami, Shyamaprosad;Das, Avijit Kumar;Abdel-Aziz, Hatem A.
利用次氯酸盐（OCl-）的氧化性质，设计合成了一种新型手性酸（（S）-（-）-2-吡咯烷酮-5-羧酸）罗丹明酰肼（RHHP），用于水溶液中绝对检测纳摩尔水平的OCl-。通过X射线衍射分析证实了手性传感器的结构。该探针具有良好的生物活性，可用于天然水体中OCl-的检测。还提出了一个合理的机制氧化的传感器，然后水解。对OCl-的受体的敏感性进行了研究，在绝对的水介质中，次氯酸盐介导的氧化的受体在纳摩尔水平的检测限，使这个平台（RHHP）的OCl-氧化的超灵敏和独特的系统。
By employing the oxidation property of hypochlorite (OCl-), a novel rhodamine-based hydrazide of the chiral acid ((S)-(-)-2-pyrrolidone-5-carboxylic acid) (RHHP) was designed and synthesized for detection of OCl- absolutely in aqueous medium at nanomolar level. The structure of the chiral sensor was also proved by the X-ray crystallography. The bioactivity and the application of the probe for detection of OCl- in natural water system have been demonstrated. A plausible mechanism for oxidation of the sensor followed by hydrolysis is also proposed. The sensibility of the receptor toward OCl- was studied in absolute aqueous media, and the detection limit of hypochlorite-mediated oxidation to the receptor in nanomolar level makes this platform (RHHP) an ultrasensitive and unique system for OCl- oxidation.