Effect of calcium channel blockers alone and in combination with antiglaucoma medications on intraocular pressure in the primate eye.
Effect of calcium channel blockers alone and in combination with antiglaucoma medications on intraocular pressure in the primate eye.
复制标题
单独使用钙通道阻滞剂以及与抗青光眼药物联合使用对灵长类动物眼眼压的影响。
DOI：
10.1097/00061198-200008000-00009
复制
发表时间：
2000
期刊：
影响因子：
--
通讯作者：
Erickson,KA
中科院分区：
文献类型：
--
作者：
Siegner,SW;Netland,PA;Schroeder,A;Erickson,KA
Purpose: To determine the effect of representative members from six classes of calcium channel blockers on intraocular pressure in the primate eye. Other antiglaucoma medications were administered with verapamil to determine their combined effect on intraocular pressure.Methods: Six healthy cynomolgus monkeys were anesthetized, and baseline intraocular pressure was measured. Drug-containing solution (50 [mu] L) was instilled in one eye and intraocular pressure was measured in both eyes 90 minutes later.Results: All classes of calcium channel blockers significantly lowered intraocular pressure in the treated eye. The percent reduction in intraocular pressure compared with the baseline pressure was 10% for verapamil (P< 0.002), 18% for nifedipine (P< 0.001), 15% for diltiazem (P< 0.001), 17% for flunarizine (P< 0.001), 19% for prenylamine (P< 0.001), and 6% for perhexiline (P< 0.01). In the fellow eye, a significant reduction in intraocular pressure was also seen with all calcium channel blockers except perhexiline, which suggested a crossover effect. In contrast, neither vehicle treated nor contralateral eyes showed a lowering of intraocular pressure when tested under the same conditions. In the treated eye, 0.5% timolol (P< 0.01) and 0.05% clonidine (P< 0.02) combined with 0.25% verapamil each appeared to produce an additive effect, with a significantly greater pressure-lowering effect than either agent alone. In addition, 0.005% pilocarpine (P< 0.001) and 0.00125% demecarium (P< 0.01) combined with 0.25% verapamil each appeared to produce a synergistic effect, with a significantly greater reduction in intraocular pressure than both agents combined.Conclusions: Topical calcium channel blockers and combinations of verapamil with antiglaucoma medications may provide a useful alternative for reducing intraocular pressure in patients with ocular hypertension or primary open-angle glaucoma.
