Parental Smoking Exposure and Adolescent Smoking Trajectories
Parental Smoking Exposure and Adolescent Smoking Trajectories
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DOI：
10.1542/peds.2013-3003
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发表时间：
2014-06-01
期刊：
影响因子：
8
通讯作者：
Niaura, Raymond S.
中科院分区：
文献类型：
--
作者：
Mays, Darren;Gilman, Stephen E.;Niaura, Raymond S.
目的：在一项吸烟风险的多代研究中，目的是通过检查父母吸烟和尼古丁依赖是否能预测青少年后代的未来吸烟轨迹，来调查吸烟的代际传播。方法：12至17岁的青少年（n = 406）和家长完成基线访谈（2001-2004），青少年在1年和5年后完成最多2次随访访谈。基线访谈收集了父母吸烟史的详细信息，包括时间和持续时间、当前吸烟情况和尼古丁依赖性。在每个时间点对青少年吸烟和尼古丁依赖进行评估。潜在类别增长分析确定了从青春期到青年期的潜在吸烟轨迹类别。采用Logistic回归检验父母吸烟与青少年吸烟轨迹之间的关系。结果：青少年吸烟轨迹分为四类：早期经常吸烟者（6%）、早期实验者（23%）、晚期实验者（41%）和不吸烟者（30%）。父母在基线时是尼古丁依赖吸烟者的青少年，每多接触一年父母吸烟，就更有可能成为早期的常规吸烟者（优势比1.18,95%可信区间1.05-1.33）和早期的实验者（优势比1.04,95%可信区间1.04-1.25）。父母目前不依赖尼古丁和以前吸烟与青少年吸烟轨迹无关。结论：父母尼古丁依赖是影响吸烟代际遗传的关键因素。父母对尼古丁依赖的青少年更容易受到更强烈的吸烟模式的影响，这种风险随着接触时间的延长而增加。需要进行研究，优化干预措施，帮助依赖尼古丁的父母在孩子的一生中尽早戒烟，以减少这些风险。
OBJECTIVE: In a multigenerational study of smoking risk, the objective was to investigate the intergenerational transmission of smoking by examining if exposure to parental smoking and nicotine dependence predicts prospective smoking trajectories among adolescent offspring.METHODS: Adolescents (n = 406) ages 12 to 17 and a parent completed baseline interviews (2001-2004), and adolescents completed up to 2 follow-up interviews 1 and 5 years later. Baseline interviews gathered detailed information on parental smoking history, including timing and duration, current smoking, and nicotine dependence. Adolescent smoking and nicotine dependence were assessed at each time point. Latent Class Growth Analysis identified prospective smoking trajectory classes from adolescence into young adulthood. Logistic regression was used to examine relationships between parental smoking and adolescent smoking trajectories.RESULTS: Four adolescent smoking trajectory classes were identified: early regular smokers (6%), early experimenters (23%), late experimenters (41%), and nonsmokers (30%). Adolescents with parents who were nicotine-dependent smokers at baseline were more likely to be early regular smokers (odds ratio 1.18, 95% confidence interval 1.05-1.33) and early experimenters (odds ratio 1.04, 95% confidence interval 1.04-1.25) with each additional year of previous exposure to parental smoking. Parents' current non-nicotine-dependent and former smoking were not associated with adolescent smoking trajectories.CONCLUSIONS: Exposure to parental nicotine dependence is a critical factor influencing intergenerational transmission of smoking. Adolescents with nicotine-dependent parents are susceptible to more intense smoking patterns and this risk increases with longer duration of exposure. Research is needed to optimize interventions to help nicotine-dependent parents quit smoking early in their children's lifetime to reduce these risks.