HIV and complement: hijacking an immune defense
HIV and complement: hijacking an immune defense
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DOI：
10.1016/j.biopha.2006.07.087
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发表时间：
2006-11-01
影响因子：
7.5
通讯作者：
Rappaport, J.
中科院分区：
文献类型：
--
作者：
Datta, P. K. .;Rappaport, J.
补体系统是先天免疫系统的核心参与者。补体系统的激活保护宿主抵抗病原体。然而，不受控制的合成可能对宿主有害。本文简要综述了补体激活机制、补体C3调节机制以及补体在人类免疫缺陷病毒（HIV）发病机制中的作用，重点介绍了HIV与补体系统在NeuroAIDS和HIV相关性肾病（HIVAN）中的相互作用。(c)2006年，Elsevier Masson SAS。All rights reserved.
The complement system is a central player of the innate immune system. Activation of the complement system protects the host against pathogens. However, uncontrolled synthesis can be detrimental to host. This concise review summarizes the current understanding of the mechanism(s) of complement activation, the mechanism of C3 regulation, and the role of complement in human immunodeficiency virus (HIV) pathogenesis with emphasis on the cross-talk between HIV and complement system in NeuroAIDS and HIV-associated nephropathy (HIVAN). (c) 2006 Elsevier Masson SAS. All rights reserved.