Naming actions and objects:: cortical dynamics in healthy adults and in an anomic patient with a dissociation in action/object naming
Naming actions and objects:: cortical dynamics in healthy adults and in an anomic patient with a dissociation in action/object naming
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DOI：
10.1016/s1053-8119(03)00217-9
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发表时间：
2003-08-01
期刊：
影响因子：
5.7
通讯作者：
Salmelin, R
中科院分区：
文献类型：
--
作者：
Sörös, P;Cornelissen, K;Salmelin, R
神经心理学研究表明，失语症患者名词和动词的产生可以分离。这些报告被认为是人类大脑中名词和动词分开表征的证据。我们使用全头脑磁图记录皮质动力学的行动和对象命名在10个健康的成年人和1个anomic患者的动词命名优于名词相比，由于左后顶叶病变。一组100个线条图用于动作和对象命名。在正常受试者中，动作和物体命名的激活序列基本上是相同的，从枕叶到后颞顶，再到左额叶皮质，没有经典的左下额叶（Broca）和颞叶（Wernicke）语言区的一致参与。在失名症患者中，左半球出现了动作和物体命名之间的明显差异。激活序列在受损的顶叶皮层水平被破坏，即使在相对容易的动作命名中也没有到达左额叶皮层。更严重受损的对象命名与异常强烈和早期激活的左下额叶皮层（布罗卡）和随后的显着激活左中颞叶皮层，沉默的行动命名。因此，动词和名词检索在健康个体中利用时空相似的神经元网络。只有在我们的失名患者中，动词和名词提取的皮层相关性才出现明显的分离，语言网络的损伤导致他们在物体命名方面的表现比动作命名更差。(C)2003年爱思唯尔公司All rights reserved.
Neuropsychological studies have demonstrated that the production of nouns and verbs can be dissociated in aphasia. These reports have been taken as evidence for separate representations of nouns and verbs in the human brain. We used whole-head magnetoencephalography to record cortical dynamics of action and object naming in 10 healthy adults and in 1 anomic patient with superior naming of verbs compared with nouns due to a left posterior parietal lesion. A single set of 100 line drawings was used for both action and object naming. In normal subjects, the activation sequences in action and object naming were essentially identical, advancing from the occipital to posterior temporoparietal and further to the left frontal cortex, without consistent involvement of the classical left inferior frontal (Broca) and temporal (Wernicke) language areas. In the anomic patient, pronounced differences between action and object naming emerged in the left hemisphere. The activation sequence was disrupted at the level of the damaged parietal cortex and did not reach the left frontal cortex even in the relatively easier action naming. The more severely impaired object naming was associated with exceptionally strong and early activation of the left inferior frontal cortex (Broca) and subsequent pronounced activation of the left middle temporal cortex, silent in action naming. Verb and noun retrieval thus utilized a spatiotemporally similar neuronal network in healthy individuals. A clear dissociation in cortical correlates of verb and noun retrieval only became evident in our anomic patient, in whom damage to the language network has resulted in disproportionately worse performance in object than action naming. (C) 2003 Elsevier Inc. All rights reserved.