Structure and Function of the 26S Proteasome.
Structure and Function of the 26S Proteasome.
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DOI：
10.1146/annurev-biochem-062917-011931
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发表时间：
2018-06-20
影响因子：
16.6
通讯作者：
Martin A
中科院分区：
文献类型：
--
作者：
Bard JAM;Goodall EA;Greene ER;Jonsson E;Dong KC;Martin A
作为泛素-蛋白酶体系统的终点，26S蛋白酶体是真核细胞中负责调节蛋白质降解的主要蛋白水解机器。蛋白酶体的细胞功能范围从一般的蛋白质稳态和应激反应到细胞分裂和信号转导等重要过程的控制。为了在复杂的细胞环境中可靠地处理呈现给它的所有蛋白质，蛋白酶体必须结合高混杂性和特殊的底物选择性。最近的结构和生化研究揭示了蛋白酶体底物加工的许多步骤，包括识别、去泛素化和atp驱动的易位和展开。此外，这些研究揭示了一个复杂的构象景观，确保在蛋白酶体进行过程降解之前适当的底物选择。我们对蛋白酶体复杂机制的理解的这些进展为未来研究蛋白酶体如何作为真核蛋白质组的主要调节剂发挥作用奠定了基础。
As the endpoint for the ubiquitin-proteasome system, the 26S proteasome is the principal proteolytic machine responsible for regulated protein degradation in eukaryotic cells. The proteasome’s cellular functions range from general protein homeostasis and stress response to the control of vital processes such as cell division and signal transduction. To reliably process all the proteins presented to it in the complex cellular environment, the proteasome must combine high promiscuity with exceptional substrate selectivity. Recent structural and biochemical studies have shed new light on the many steps involved in proteasomal substrate processing, including recognition, deubiquitination, and ATP-driven translocation and unfolding. In addition, these studies revealed a complex conformational landscape that ensures proper substrate selection before the proteasome commits to processive degradation. These advances in our understanding of the proteasome’s intricate machinery set the stage for future studies on how the proteasome functions as a major regulator of the eukaryotic proteome.
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影响因子：
5.6
作者：
de Poot SAH;Tian G;Finley D
通讯作者：
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影响因子：
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DOI：
10.1073/pnas.1614614113
发表时间：
2016-11-15
影响因子：
11.1
作者：
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通讯作者：
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作者：
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影响因子：
64.5
作者：
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