BETA-RECEPTOR-MEDIATED INCREASE IN CEREBRAL BLOOD-FLOW DURING HYPOGLYCEMIA
BETA-RECEPTOR-MEDIATED INCREASE IN CEREBRAL BLOOD-FLOW DURING HYPOGLYCEMIA
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DOI：
10.1152/ajpheart.1987.253.4.h949
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发表时间：
1987-10-01
影响因子：
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通讯作者：
BRYAN, RM
中科院分区：
文献类型：
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作者：
HOLLINGER, BR;BRYAN, RM
我们检验了假设。-肾上腺素能受体刺激与低血糖时局部脑血流量（rCBF）增加有关。采用氟烷-氧化亚氮麻醉对大鼠进行手术制备。在后腿周围放置石膏约束石膏，并停止麻醉。静脉注射胰岛素（15u /kg）产生低血糖；给予血糖控制正常的大鼠生理盐水。给一些对照大鼠和一些低血糖大鼠给予心得安（1.5 mg/kg）阻断。肾上腺素能受体。用4-[n -甲基- 14c]碘安替比林测定区域脑血流。正常血糖组和低血糖组血浆葡萄糖约为。6和1.4亩。分别g / ml。未给予心得安的大鼠在低血糖期间脑血流增加。增长幅度从。60%到200%取决于大脑区域。在低血糖期间，心得安消除了下丘脑、小脑和锥体束中rCBF的增加。在其他地区，rCBF的增加仅为未使用心得安治疗的低血糖大鼠的33-65%。我们的结论是。-受体刺激在低血糖时rCBF增加中起主要作用。
We tested the hypothesis that .beta.-adrenergic receptor stimulation is involved with the increase in regional cerebral blood flow (rCBF) during hypoglycemia. Rats were surgically prepared with the use of halothane-nitrous oxide anesthesia. A plaster restraining cast was placed around the hindquarters, and anesthesia was discontinued. Hypoglycemia was produced by an intravenous injection of insulin (15 U/kg); normoglycemic control rats were given saline. Propranolol (1.5 mg/kg) was administered to some control and some hypoglycemic rats to block the .beta.-adrenergic receptors. Regional CBF was measured using 4-[N-methyl-14C]iodoantipyrine. Plasma glucose in the normoglycemic and hypoglycemic groups was .apprx.6 and 1.4 .mu.g/ml respectively. Regional CBF increased during hypoglycemia in rats that were not treated with propranolol. The increase varied from .apprx.60 to 200% depending on the brain region. During hypoglycemia, propranolol abolished the increase in rCBF in the hypothalamus, cerebellum, and pyramidal tract. In other regions the increase in rCBF was only 33-65% of the increase in hypoglycemic rats that were not treated with propranolol. We conclude that .beta.-receptor stimulation plays a major role in the increase in rCBF during hypoglycemia.