Microfilament-Membrane Interactions in Cell Shape and Surface Architecture
Microfilament-Membrane Interactions in Cell Shape and Surface Architecture
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细胞形状和表面结构中的微丝-膜相互作用
DOI：
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发表时间：
1981
期刊：
影响因子：
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通讯作者：
J. Condeelis
中科院分区：
文献类型：
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作者：
J. Condeelis
自1963年第一次关于细胞运动的会议（Allen和Kamiya）以来，已经获得了大量证据，证明肌球蛋白和肌动蛋白丝之间的滑动相互作用为真核细胞表现出的许多形式的运动提供动力，如肌肉收缩、变形虫运动、细胞质流动、细胞形状的变化、跃迁颗粒运动、细胞表面成分的重新分配、内吞作用和胞外作用（Taylor and Condeelis 1979; Condeelis 1980）。关于肌动蛋白和肌凝蛋白之间的滑动相互作用如何移动细胞及其成分，一个合乎逻辑且必要的假设是，这两种蛋白质中的一种或两种必须附着在细胞膜上。对微丝-膜相互作用的文献进行简单的调查，可以提供生化（Wickus et al. 1975; Weihing 1976; Ceccarini et al. 1978; Spudich 1974; Koch and Smith 1978; Condeelis 1979）和形态学（Pollard and Korn 1973; Mooseker and Tilney 1975; Schroeder 1973; Goldman et al. 1976; Begg et al. 1978; Condeelis 1979; Salisbury et al. 1980）证据证明这种相互作用的发生。从这些研究中也可以清楚地看出，微丝膜相互作用的形态和稳定性差异可能对这些结构的功能具有重要意义。这些差异也表明，微丝-膜相互作用的发生可能有多种机制，尽管这些机制尚未得到阐明。
Since the first conference on cell motility in 1963 (Allen and Kamiya) substantial evidence has been acquired that sliding interactions between myosin and filaments of actin power many forms of motility exhibited by eucaryotic cells such as muscle contraction, amoeboid movement, cytoplasmic streaming, changes in cell shape, saltatory particle movement, redistribution of cell surface components, endocytosis and exocytosis (Taylor and Condeelis 1979; Condeelis 1980). A logical and necessary assumption in how sliding interactions between actin and myosin move the cell and its components is that either one or both of these proteins must be attached to cell membranes. A brief survey of the literature for examples of microfilament-membrane interactions provides both biochemical (Wickus et al. 1975; Weihing 1976; Ceccarini et al. 1978; Spudich 1974; Koch and Smith 1978; Condeelis 1979) and morphological (Pollard and Korn 1973; Mooseker and Tilney 1975; Schroeder 1973; Goldman et al. 1976; Begg et al. 1978; Condeelis 1979; Salisbury et al. 1980) evidence that such interactions occur. It is also clear from these studies that microfilamentmembrane interactions occur with differences in morphology and stability that are probably significant for the function of these structures. These differences also suggest that there may be multiple mechanisms by which microfilament-membrane interactions occur although as yet none of these mechanisms have been elucidated.