Serum C-reactive protein level and prediabetes in two Asian populations
Serum C-reactive protein level and prediabetes in two Asian populations
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DOI：
10.1007/s00125-011-2052-5
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发表时间：
2011-04-01
期刊：
影响因子：
8.2
通讯作者：
Wong, T. Y.
中科院分区：
文献类型：
--
作者：
Sabanayagam, C.;Shankar, A.;Wong, T. Y.
糖尿病前期是高血压连续体的早期阶段，会增加未来发生糖尿病和心血管疾病（CVD）的风险。C-反应蛋白（CRP）是一种炎症标志物，与糖尿病和CVD相关。然而，在无糖尿病的受试者中研究CRP和前驱糖尿病之间的关联的研究是有限的。我们分析了来自新加坡的两项大型人群研究的数据：新加坡前瞻性研究方案（SP2，n = 4，252名华人、马来人和印度人，年龄为千分之一日元24岁）和新加坡马来人眼科研究（SiMES，n = 2，337名40-80岁的马来人），其中参与者没有糖尿病。糖尿病前期定义为SiMES中糖化血红蛋白为5.7-6.4%（n = 1，231）; SP2中空腹血糖为5.6-6.9 mmol/l（n = 386）。在调整年龄、性别、种族、教育、吸烟、饮酒、高血压、BMI和总胆固醇后，发现高敏C反应蛋白（hsCRP）水平与糖尿病前期相关。与hsCRP < 1 mg/l的患者相比，（referent），或在hsCRP 1-3 mg/l和> 3 mg/l的人群中，糖尿病前期的95%置信区间为1.31（0.99-1.74）和2.17（1.61-2.92），SP2中p（趋势）< 0.0001; SiMES中1.23（1.00-1.52）和1.31（1.06-1.64），p（趋势）= 0.02。在亚组分析中，女性、中国人和马来人以及BMI < 25 kg/m2的受试者中，这种相关性更强。来自两个亚洲人群队列的数据表明，血清hsCRP水平升高与糖尿病前期相关。
Prediabetes, an early stage in the hyperglycaemic continuum, increases the future risk of developing diabetes and cardiovascular disease (CVD). C-reactive protein (CRP), a marker of inflammation, is associated with diabetes and CVD. However, studies examining the association between CRP and prediabetes among participants without diabetes are limited.We analysed data from two large population-based studies in Singapore: the Singapore Prospective Study Programme (SP2, n = 4,252 Chinese, Malay and Indians aged a parts per thousand yen24 years) and the Singapore Malay Eye Study (SiMES, n = 2,337 Malays aged 40-80 years), participants of which were free of diabetes mellitus. Prediabetes was defined as glycated haemoglobin of 5.7-6.4% in SiMES (n = 1,231); fasting plasma glucose of 5.6-6.9 mmol/l in SP2 (n = 386).Elevated high sensitivity CRP (hsCRP) levels were found to be associated with prediabetes after adjusting for age, sex, race-ethnicity, education, smoking, alcohol consumption, hypertension, BMI and total cholesterol. Comparing those with hsCRP < 1 mg/l (referent), the OR (95% confidence interval) of prediabetes in persons with hsCRP 1-3 mg/l and > 3 mg/l was 1.31 (0.99-1.74) and 2.17 (1.61-2.92), p (trend) < 0.0001 in SP2; 1.23 (1.00-1.52) and 1.31 (1.06-1.64), p (trend) = 0.02 in SiMES. In subgroup analysis, the association was stronger in women, Chinese and Malays, and participants with BMI < 25 kg/m(2).Data from two population-based Asian cohorts suggest that elevated serum hsCRP levels are associated with prediabetes.