Perfluorocarbons: Life sciences and biomedical uses - Dedicated to the memory of Professor Guy Ourisson, a true RENAISSANCE man.
Perfluorocarbons: Life sciences and biomedical uses - Dedicated to the memory of Professor Guy Ourisson, a true RENAISSANCE man.
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DOI：
10.1002/pola.21937
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发表时间：
2007-04-01
影响因子：
--
通讯作者：
Riess, Jean G.
中科院分区：
文献类型：
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作者：
Krafft, Marie Pierre;Riess, Jean G.
全氟化碳的主要特点是具有出色的化学和生物惰性，以及强烈的疏水和疏脂作用。后者的作用提供了一个强大的非共价，不稳定的结合相互作用，可以促进选择性自组装。全氟化合物不能模拟自然，但它们可以为功能生物聚合物的从头设计和生理重要问题的替代解决方案提供非生物构建模块。它们提供了用于分子识别、选择性分选和模板结合的新标签（例如，选择性肽和核酸配对）。它们还稳定膜并提供微米和纳米区室的氟环境。全氟碳化合物为使用微流体技术的芯片实验室实验和分析提供惰性非极性载体流体。低水溶性加上高蒸气压，可以稳定可注射微泡，作为诊断超声成像的造影剂。高气体溶解度是用于血管内氧气输送的非生物手段的基础。碳氟化合物的其他生物医学应用包括肺表面活性剂替代和眼科辅助。具有碳氟化合物相和/或壳的各种胶体正在研究用于使用超声或磁共振的分子成像以及用于靶向药物递送。高度氟化的聚合物提供了一系列惰性材料（例如，氟硅，膨胀聚四氟乙烯）用于隐形眼镜，重建手术（例如，血管移植物）和其它装置。(c)2007 Wiley Periodicals，Inc.
Perfluorocarbons are primarily characterized by outstanding chemical and biological inertness, and intense hydrophobic and lipophobic effects. The latter effects provide a powerful noncovalent, labile binding interaction that can promote selective self-assembly. Perfluoro compounds do not mimic nature, yet they can offer abiotic building blocks for the de novo design of functional biopolymers and alternative solutions to physiologically vital issues. They offer new tags useful for molecular recognition, selective sorting, and templated binding (e.g., selective peptide and nucleic acid pairing). They also stabilize membranes and provide micro-and nanocompartmented fluorous environments. Perfluorocarbons provide inert, apolar carrier fluids for lab-on-a-chip experiments and assays using microfluidic technologies. Low water solubility, combined with high vapor pressure, allows stabilization of injectable microbubbles that serve as contrast agents for diagnostic ultrasound imaging. High gas solubilities are the basis for an abiotic means for intravascular oxygen delivery. Other biomedical applications of fluorocarbons include lung surfactant replacement and ophthalmologic aids. Diverse colloids with fluorocarbon phases and/or shells are being investigated for molecular imaging using ultrasound or magnetic resonance, and for targeted drug delivery. Highly fluorinated polymers provide a range of inert materials (e.g., fluorosilicons, expanded polytetrafluoroethylene) for contact lenses, reconstructive surgery (e.g., vascular grafts), and other devices. (c) 2007 Wiley Periodicals, Inc.