Protein tentacles
Protein tentacles
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DOI：
10.1016/j.jsb.2017.05.012
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发表时间：
2017-12-01
影响因子：
3
通讯作者：
Harrison, Stephen C.
中科院分区：
文献类型：
--
作者：
Harrison, Stephen C.
病毒结构是最早的例证之一，说明了蛋白质组装是如何通过多肽链片段折叠成伴侣蛋白上的互补位点来进行的。我借鉴卡斯帕关于蛋白质“触角”的形象，以及他将SV40五聚体比喻为五条腿的水生生物（“五聚体”），以提出一个有用的词汇。组件亚基之间的“触手相互作用”组织了大多数亚细胞分子机器。它们的选择性优势包括通过修饰酶和折叠分子伴侣容易调节组装和拆卸。(c)2017爱思唯尔公司All rights reserved.
Virus structures were among the earliest illustrations of how regulated protein assembly can proceed by folding of polypeptide-chain segments into complementary sites on partner proteins. I draw on Caspar's image of protein "tentacles" and his metaphor of SV40 pentamers as five-legged, aquatic organisms ("pentopuses") to suggest a helpful vocabulary. "Tentacular interactions" among component subunits organize most subcellular molecular machines. Their selective advantages include facile regulation of both assembly and disassembly by modifying enzymes and by folding chaperones. (c) 2017 Elsevier Inc. All rights reserved.