Efficacy of continuous low-dose hANP administration in patients undergoing emergent coronary artery bypass grafting for acute coronary syndrome.
Efficacy of continuous low-dose hANP administration in patients undergoing emergent coronary artery bypass grafting for acute coronary syndrome.
复制标题
连续低剂量 hANP 给药对因急性冠状动脉综合征而接受紧急冠状动脉旁路移植术的患者的疗效。
作者：
A. Sezai;M. Hata;S. Wakui;T. Niino;T. Takayama;A. Hirayama;S. Saito;K. Minami
背景
在心脏手术期间低剂量持续人心房钠尿肽（hANP）的管理已被报道。在本研究中，对急性冠状动脉综合征（ACS）急诊冠状动脉旁路移植术（CABG）期间的治疗效果进行了研究。
方法和结果
将124例因ACS接受急诊CABG的患者分为2组;接受hANP给药的组（hANP组）和未接受hANP输注的组（non-hANP组）。hANP组术后肌酸激酶-MB峰值水平明显低于非hANP组。hANP组术后心律失常的发生率也明显低于非hANP组。hANP组术后脑钠素水平显著低于非hANP组，直至术后1年。hANP组术后无心脏事件发生率也明显高于非hANP组。
结论
因此，认为hANP不仅可以有效地克服心肺转流的一些主要缺点，而且可以有效地减轻缺血再灌注损伤，保护心肌，具有抗心肌病作用，并抑制左心室重构。
BACKGROUND
Low-dose continuous human atrial natriuretic peptide (hANP) administration during cardiac surgery has been reported on previously. In the present study, the efficacy of the therapy during emergent coronary artery bypass grafting (CABG) for acute coronary syndrome (ACS) is investigated.
METHODS AND RESULTS
One hundred and twenty-four patients patients undergoing emergent CABG for ACS were divided into 2 groups; a group receiving administration of hANP (hANP group) and a group not receiving hANP infusion (non-hANP group). The postoperative peak levels of creatine kinase-MB were significantly lower in the hANP group as compared with those in the non-hANP group. The incidence of postoperative arrhythmias was also significantly lower in the hANP group as compared with that in the non-hANP group. The postoperative brain natriuretic peptide was significantly lower in the hANP group as compared with that in the non-hANP group until 1 year after the operation. The free-rate of cardiac events after the operation was also significantly higher in the hANP group as compared with that in the non-hANP group.
CONCLUSIONS
It is therefore considered that hANP might not only be effective for overcoming some major shortcomings of cardiopulmonary bypass, but also might be effective to attenuate ischemia-reperfusion injury, protect the myocardium, have an anti-arrhythmic effect, and suppress left ventricular remodeling.
影响因子：
37.8
作者：
CHU, A;MORRIS, KG;COBB, FR
通讯作者：
COBB, FR