Serum leptin through childhood and adolescence
Serum leptin through childhood and adolescence
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DOI：
10.1046/j.1365-2265.1997.2081026.x
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发表时间：
1997-06-01
影响因子：
3.2
通讯作者：
Price, DA
中科院分区：
文献类型：
--
作者：
Clayton, PE;Gill, MS;Price, DA
目的瘦素（Leptin）是新近克隆的ob基因的蛋白产物，它不仅参与体重和产热的调控，而且还独立地刺激生殖轴。由于身体组成和性腺功能的主要变化发生在人类青春期，我们已经评估了整个儿童期的血清瘦素浓度。受试者和测量在放射免疫测定法中测量了来自235名5至18岁健康儿童的样品中的血清瘦素。与体重指数（BMI）的关系（以标准差评分（SDS）表示），并分析了青春期各阶段内性别内和性别间的浓度变化，结果青春期前男女血清瘦素水平相似，进入青春期早期（乳房期（B）2，生殖期（G）2）时血清瘦素水平平行升高，此后男孩血清瘦素水平下降，至G5时降至最低点，女孩血清瘦素水平在青春期中期保持稳定，至B5时达到高峰。影响瘦素的因素因此，在青春期前和围青春期阶段评估BMI SDS、年龄和睾丸体积（B1-2，G1-2）与青春期后期相比B3-5、G3-5组瘦素水平与BMI、SDS呈正相关（女孩r（2）=38-41%，男孩r（2）=31- 3 - 5%），B1-2、G1-2组瘦素水平与BMI、SDS呈正相关（女孩r（2）=38-41%，男孩r（2）=31- 3 - 5%），瘦素与年龄呈正相关，分别贡献27%和20%的变异性，在B3-5中，年龄仅贡献5%的变异性。在G3-5，瘦素与BMI SDS呈正相关（r（2）=35%），与睾丸体积呈负相关（r（2）= 24%.CONCLUSIONS BMI对瘦素的影响在整个青春期前和青春期都是一个重要因素，睾丸体积在男孩中的附加负效应有助于青春期结束时瘦素浓度的性别二分法。在青春期前的几年中，瘦素在两种性别的青春期早期的类似的上升，不仅与BMI SDS，但也独立于年龄，这表明瘦素可能有一个促进作用，在人类青春期发育。
OBJECTIVE Leptin is the protein product of the recently cloned ob gene, that has been implicated in the control of body weight and thermogenesis, but also independently stimulates the reproductive axis. As major changes in body composition and gonadal function occur during human adolescence, we have assessed serum leptin concentration through childhood,SUBJECTS AND MEASUREMENTS Serum leptin was measured in a radioimmunoassay in samples from 235 healthy children from 5 to 18 years of age, Its; relationship to body mass index (BMI) (expressed as standard deviation score (SDS)) and the changes in concentration both within and between sexes over the stages of puberty were analysed,RESULTS Serum leptin was present at similar concentrations in both sexes over the prepubertal years and increased in parallel into early puberty (breast stage (B) 2, genital stage (G) 2), Thereafter serum leptin in the boys declined to a nadir in G5, In contrast in girls, leptin remained constant in mid-puberty rising to a peak at B5. Factors influencing leptin (BMI SDS, age and testicular volume) were assessed therefore in the pre- and peripubertal stages (B1-2, G1-2) compared to the later pubertal stages (B3-5, G3-5), In all groups, leptin was positively correlated to BMI SDS (r(2)=38-41% in girls, r(2)=31-35% in boys), However in B1-2 and G1-2, leptin was also positively related to age, which contributed a further 27% and 20% respectively to the variability, In B3-5, age only accounted for an additional 5% in leptin variability. In contrast in G3-5, leptin was related positively to BMI SDS (r(2)=35%) and negatively to testicular volume (r(2)=24%).CONCLUSIONS The influence of BMI on leptin is a significant factor throughout the prepubertal and pubertal years of both sexes, The additional negative effect of testicular volume in the boys contributes to the sexual dichotomy in leptin concentration at the completion of puberty, The similar rise in leptin over the prepubertal years into early puberty in both sexes, related not only to BMI SDS but also independently to age, would suggest that leptin may have a facilitatory role in human pubertal development.