New model of vincristine-induced neuropathic pain in children: a first step towards prediction and prevention.
New model of vincristine-induced neuropathic pain in children: a first step towards prediction and prevention.
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DOI：
10.1097/j.pain.0000000000000981
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发表时间：
2017-09
期刊：
影响因子：
7.4
通讯作者：
Fitzgerald M
中科院分区：
文献类型：
--
作者：
Fitzgerald M
这是一个不幸的事实的生活，我们的理解儿科神经性疼痛落后于成人，尽管有明确的证据表明，临床需要。5，7，14这种疼痛的一个重要来源是长春新碱，一种常用于治疗儿科癌症的长春花生物碱，它会引起大量的神经毒性和神经性疼痛。虽然周围神经病变是长春新碱治疗的公认副作用，但长春新碱诱导的神经病变（VIPN）对儿童生活质量的发生率、严重程度和长期后果尚不清楚。10这种知识差距部分是因为缺乏公认的临床可行的评估工具，在儿科人群，但也是因为缺乏一个生物学机制的理解，如何产生和维持VIPN疼痛在children. the future is substantially brighter than the publication of first，well-defined，大鼠模型化疗诱导的神经性疼痛在生命早期。在本卷疼痛中，12 Schappacher、Styczynski和Baccei在10 - 21日龄大鼠中使用了谨慎的全身长春新碱给药方案，以成功平衡所需的神经毒性与大鼠幼仔的健康状况，并产生了令人信服的VIPN疼痛模型，测量为显著和持久的行为机械超敏反应。
It is an unfortunate fact of life that our understanding of paediatric neuropathic pain lags behind that of adults, despite clear evidence of clinical need. 5, 7, 14 One important source of such pain is vincristine, a vinca alkaloid commonly used to treat paediatric cancers, which causes substantial neurotoxicity and neuropathic pain. Although peripheral neuropathy is a wellrecognized side effect of vincristine therapy, the incidence, severity, and the long-term consequences of vincristine-induced neuropathy (VIPN) on the quality of life in children are not well understood. 10 This knowledge gap is partly because of the lack of accepted and clinically feasible assessment tools in pediatric populations but is also because of the lack of a biological mechanistic understanding of how VIPN pain is generated and maintained in children.The future is therefore substantially brighter following the publication of the first, well-defined, rat model of chemotherapyinduced neuropathic pain in early life. In this volume of PAIN, 12 Schappacher, Styczynski, and Baccei use a careful systemic vincristine dosing regime in rats aged 10 to 21 days old to successfully balance the required neurotoxicity with the wellbeing of the rat pups and produce a convincing model of VIPN pain, measured as a significant and long-lasting behavioural mechanical hypersensitivity.
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影响因子：
7.4
作者：
Schappacher KA;Styczynski L;Baccei ML
通讯作者：
Baccei ML
影响因子：
5.3
作者：
McKelvey, Rebecca;Berta, Temugin;Fitzgerald, Maria
通讯作者：
Fitzgerald, Maria
DOI：
10.1111/jns.12114
发表时间：
2015-03
期刊：
Journal of the peripheral nervous system : JPNS
影响因子：
--
作者：
Lavoie Smith EM;Li L;Chiang C;Thomas K;Hutchinson RJ;Wells EM;Ho RH;Skiles J;Chakraborty A;Bridges CM;Renbarger J
通讯作者：
Renbarger J
影响因子：
5.3
作者：
Fitzgerald M;McKelvey R
通讯作者：
McKelvey R
影响因子：
120.7
作者：
Diouf, Barthelemy;Crews, Kristine R.;Lew, Glen;Pei, Deqing;Cheng, Cheng;Bao, Ju;Zheng, Jie J.;Yang, Wenjian;Fan, Yiping;Wheeler, Heather E.;Wing, Claudia;Delaney, Shannon M.;Komatsu, Masaaki;Paugh, Steven W.;McCorkle, Joseph Robert;Lu, Xiaomin;Winick, Naomi J.;Carroll, William L.;Loh, Mignon L.;Hunger, Stephen P.;Devidas, Meenakshi;Pui, Ching-Hon;Dolan, M. Eileen;Relling, Mary V.;Evans, William E.
通讯作者：
Evans, William E.