Thermoresponsive liquid crystalline polymer membranes that undergo phase transition at body temperature
Thermoresponsive liquid crystalline polymer membranes that undergo phase transition at body temperature
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DOI：
10.1016/j.memsci.2019.117213
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发表时间：
2019-10-15
影响因子：
9.5
通讯作者：
Miyata, Takashi
中科院分区：
文献类型：
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作者：
Inoue, Yasuaki;Atsumi, Yuya;Miyata, Takashi
生物膜通过响应于环境因素（例如pH、温度和生物分子浓度）的变化而在其组织结构和流动性中发生剧烈变化来调节其性质和功能。液晶聚合物（LCP）被广泛用作各种领域中的功能材料，因为类似于生物膜，它们在它们的相变温度下经历它们的组织结构和迁移率的突变。为了设计智能膜，调节药物的渗透性作为温度的函数，我们专注于良好组织和动态的LCP，在体温附近经历液晶各向同性相变。在这项研究中，侧链LCP组成的一个灵活的硅氧烷主链和侧基元的合成和LCP膜的制备通过浇铸LCP/二甲苯多孔支撑膜。液晶聚合物的向列相-各向同性相转变温度（T-NI）强烈依赖于液晶基元的含量。虽然药物通过LCP膜的渗透在低于T-NI的温度下受阻，但其药物渗透性大大增强。药物透过LCP膜的温度响应性调节归因于由向列相-各向同性相转变引起的其良好组织和动态结构的急剧变化。
Biological membranes regulate their properties and functions by drastic changes in their organized structure and mobility in response to changes in environmental factors such as pH, temperature, and biomolecule concentration. Liquid crystalline polymers (LCPs) are widely used as functional materials in a variety of fields because, similarly to biological membranes, they undergo abrupt changes in their organized structures and mobilities at their phase transition temperatures. In order to design smart membranes that regulate drug permeability as a function of temperature, we focused on well-organized and dynamic LCPs that undergo liquid crystalline-isotropic phase transition around body temperature. In this study, side-chain LCPs composed of a flexible siloxane main chain and pendant mesogens were synthesized and LCP membranes were prepared by casting the LCPs/xylene on porous support membranes. The nematic-isotropic phase transition temperature (T-NI) of the resulting LCPs strongly depended on the mesogen content. Although the permeation of drugs through the LCP membranes was hindered at temperatures below T-NI, their drug permeability was drastically enhanced over T-NI. Thermoresponsive regulation of drug permeation through the LCP membranes is attributed to the drastic changes in their well-organized and dynamic structures that are induced by the nematic-isotropic phase transition.