Ongoing DNA synthesis continues in young human diploid cells (HDC) fused to senescent HDC, but entry into S phase is inhibited.
Ongoing DNA synthesis continues in young human diploid cells (HDC) fused to senescent HDC, but entry into S phase is inhibited.
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与衰老 HDC 融合的年轻人类二倍体细胞 (HDC) 中继续进行正在进行的 DNA 合成，但进入 S 期受到抑制。
DOI：
10.1016/0014-4827(80)90290-6
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发表时间：
1980
影响因子：
3.7
通讯作者：
Gretchen H. Stein
中科院分区：
文献类型：
--
作者：
R. Yanishevsky;Gretchen H. Stein
先前的实验已经表明，当年轻的人类二倍体细胞（HDC）与衰老的HDC融合时，两个细胞核都不合成DNA。这篇论文证明，当年轻的HDC在与衰老的HDC融合时处于S期时，它们确实在异双核体中制造DNA;因此，正在进行的DNA合成不受衰老细胞的抑制。另一方面，进入S期被抑制：处于G1期的年轻HDC核不与衰老HDC在异双核体中制造DNA。
Previous experiments have shown that when young human diploid cells (HDC) were fused to senescent HDC, neither nucleus synthesized DNA. This paper demonstrates that when young HDC are in S phase at the time of fusion to senescent HDC, they do make DNA in heterodikaryons; therefore, ongoing DNA synthesis is not inhibited by senescent cells. On the other hand, entry into S phase is inhibited: young HDC nuclei in G1 phase do not make DNA in heterodikaryons with senescent HDC.