Chemical radiosensitization of anoxic mammalian cells: effect of cell concentration.
Chemical radiosensitization of anoxic mammalian cells: effect of cell concentration.
复制标题
缺氧哺乳动物细胞的化学放射增敏：细胞浓度的影响。
作者：
D. Agnew;L. Skarsgard
产生的剂量修正因子分别为1.5、1.8和1.8。在高细胞浓度和敏化剂的存在下照射的无色素细胞经历了两个阶段的损失，通常在稀释的细胞悬浮液中看到的大部分敏化。在形成细胞团块时，致敏作用的大部分丧失，将剂量调整因子降低至稀释细胞悬液中获得的值的约70%。随后，剩余的致敏成分缓慢消失。这种细胞浓度效应的一些可能的机制进行了讨论。这表明，细胞团实验可能被证明是一个有用的指标的放射增敏剂在体内的有效性。
produced dose-modifying factors of 1.5, 1.8, and 1.8, respectively. Anoxic cells irradiated at high cell concentrations and in the presence of a sensitizer experienced a two-stage loss of much of the sensitization normally seen in dilute cell suspension. A large component of sensitization was lost upon formation of the cell pellet, reducing the dose modifying factors to values approximately 70% of those obtained in dilute cell suspensions. This was followed by a slow disappearance of the remaining component of sensitization. Some possible mechanisms for this cell concentration effect are discussed. It is suggested that the cell pellet experiment may prove to be a useful indicator of the effectiveness of radiosensitizers in vivo.