Diphenylprolinol silyl ether as catalyst of an asymmetric, catalytic, and direct Michael reaction of nitroalkanes with α,β-unsaturated aldehydes
Diphenylprolinol silyl ether as catalyst of an asymmetric, catalytic, and direct Michael reaction of nitroalkanes with α,β-unsaturated aldehydes
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DOI：
10.1021/ol702545z
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发表时间：
2007-12-06
期刊：
影响因子：
5.2
通讯作者：
Hayashi, Yujilro
中科院分区：
文献类型：
--
作者：
Gotoh, Hiroaki;Ishikawa, Hayato;Hayashi, Yujilro
以二苯基脯氨醇硅基醚为有机催化剂，研究了硝基烷烃与α、β -不饱和醛的对映选择性直接共轭加成反应。使用这一方法作为关键步骤，短合成治疗有用的化合物也已完成。
A catalytic enantioselective direct conjugate addition of nitroalkanes to alpha,beta-unsaturated aldehydes using diphenylprolinol silyl ether as an organocatalyst has been developed. Using this methodology as a key step, short syntheses of therapeutically useful compounds have also been accomplished.