Increased morbidity associated with chronic infection by an epidemic Pseudomonas aeruginosa strain in CF patients
Increased morbidity associated with chronic infection by an epidemic Pseudomonas aeruginosa strain in CF patients
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DOI：
10.1136/thx.2003.014258
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发表时间：
2004-04-01
期刊：
影响因子：
10
通讯作者：
Walshaw, MJ
中科院分区：
文献类型：
--
作者：
Al-Aloul, M;Crawley, J;Walshaw, MJ
背景资料：有报道称，囊性纤维化（CF）患者中存在可传播的铜绿假单胞菌菌株引起的慢性肺部感染，引起了交叉感染和患者隔离的问题。第一个这样的菌株被描述（利物浦流行株，LES）现在在许多英国CF中心广泛传播。然而，这种感染是否具有更差的预后尚不清楚。为了解决这个问题，一组慢性感染LES的CF患者的临床过程进行了比较，在患者窝藏独特strains.Methods：使用铜绿假单胞菌菌株基因分型，两个队列的CF患者参加的利物浦CF服务确定谁是LES阳性或阴性，在1998年，并保持到2002年。从这些，两组12例患者在1998年匹配的年龄，肺功能参数，营养状态和他们的临床病程随访5年。结果：LES慢性感染患者的肺功能年损失率高于非LES慢性感染患者（两组间平均差异为-4.4%（95%CI为-8.1 ~-0.9; P < 0.01）），LES慢性感染患者的肺功能年损失率高于非LES慢性感染患者（P < 0.05）。
Background: Chronic pulmonary infection with transmissible Pseudomonas aeruginosa strains in individuals with cystic fibrosis (CF) has been reported, raising issues of cross infection and patient segregation. The first such strain to be described (the Liverpool epidemic strain, LES) is now widespread in many UK CF centres. However, whether such infection carries a worse prognosis is unknown. To address this, the clinical course of a group of CF patients chronically infected by LES was compared with that in patients harbouring unique strains.Methods: Using P aeruginosa strain genotyping, two cohorts of CF patients attending the Liverpool CF service were identified who were LES positive or negative in 1998 and remained so until 2002. From these, two groups of 12 patients were matched in 1998 for age, spirometric parameters, and nutritional state and their clinical course was followed for 5 years. Patients chronically infected with Burkholderia cepacia were excluded.Results: Patients chronically infected with LES had a greater annual loss of lung function than those not chronically infected by LES (mean difference between groups -4.4% (95% CI -8.1 to -0.9; p