UV-induced interaction between p38 MAPK and p53 serves as a molecular switch in determining cell fate
UV-induced interaction between p38 MAPK and p53 serves as a molecular switch in determining cell fate
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紫外线诱导的 p38 MAPK 和 p53 之间的相互作用作为决定细胞命运的分子开关
DOI：
10.1016/j.febslet.2010.10.057
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发表时间：
2010-12-01
期刊：
影响因子：
3.5
通讯作者：
Jiang, Yong
中科院分区：
文献类型：
--
作者：
Gong, Xiaowei;Liu, Aihua;Jiang, Yong
p53在DNA损伤后维持基因组完整性方面发挥着重要作用，决定细胞是修复和存活还是死亡。然而，支配其选择的规则在很大程度上尚未被发现。在这里，我们表明，p38和p53之间的功能关系是至关重要的，在定义DNA损伤后的细胞命运。在低剂量紫外线照射下，p38和p53分别保护细胞免于凋亡。相反，它们一起起作用以在高剂量UV暴露时促进细胞凋亡。MINT-8050838：p53（uniprotkb：P02340）physically interacts（MI：0915）with p38（uniprotkb：P47811）by anti bait coimmunoprecipitation（MI：0006）MINT-8050948：p53（uniprotkb：P04637）physically interacts（MI：0915）with p38（uniprotkb：P47811）by anti tag coimmunoprecipitation（MI：0007）（c）2010 Federation of European Biochemical Societies. Elsevier B. V.出版，保留所有权利。
p53 plays a fundamental role in the maintenance of genome integrity after DNA damage, deciding whether cells repair and live, or die. However, the rules that govern its choice are largely undiscovered. Here we show that the functional relationship between p38 and p53 is crucial in defining the cell fate after DNA damage. Upon low dose ultraviolet (UV) radiation, p38 and p53 protect the cells from apoptosis separately. Conversely, they function together to favor apoptosis upon high dose UV exposure. Taken together, a UV-induced, dose-dependent interaction between p38 and p53 acts as a switch to determine cell fate.Structured summary:MINT-8050838: p53 (uniprotkb:P02340) physically interacts (MI:0915) with p38 (uniprotkb:P47811) by anti bait coimmunoprecipitation (MI:0006)MINT-8050948: p53 (uniprotkb:P04637) physically interacts (MI:0915) with p38 (uniprotkb: P47811) by anti tag coimmunoprecipitation (MI:0007) (c) 2010 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.