The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis
The effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects: a systematic review with meta-analysis
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DOI：
10.1007/s00394-015-1089-5
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发表时间：
2016-09-01
影响因子：
5
通讯作者：
Stelmach-Mardas, Marta
中科院分区：
文献类型：
--
作者：
Jamka, Malgorzata;Wozniewicz, Malgorzata;Stelmach-Mardas, Marta
本系统评价的目的是评估补充维生素D对肥胖和超重受试者选定的炎症生物标志物的影响。检索过程基于以下数据库中列出的出版物（DB-RCT和RCT）的选择：PubMed、Web of Knowledge、Scopus、科克伦图书馆和Embase。为了评估研究质量，使用了根据Newcastle-Ottawa量表的9分评分系统，高质量研究的阈值为aeyen 7分。纳入13项随机对照试验。分析人群包括1955名超重和肥胖受试者。平均年龄13.6 ~ 71.7岁。评估25-羟基胆钙化醇（25（OH）D）、C反应蛋白（CRP）、肿瘤坏死因子α（TNF-α）和白细胞介素6（IL-6）浓度的变化。为了联合收割机个体研究结果，进行了荟萃分析。25（OH）D的基线水平表明分析人群中存在维生素D缺乏或不足。补充维生素D对CRP（std.平均差异-0.11; 95% CI -0.27-0.04; p = 0.15），TNF-α（标准差，平均差异-0.13; 95% CI -0.38-0.12; p = 0.31）和IL-6浓度（标准差，平均差异0.1;该荟萃分析表明，补充维生素D对肥胖和超重受试者中所选炎症生物标志物的浓度变化没有显著影响。
The objective of this systematic review was to assess the effect of vitamin D supplementation on selected inflammatory biomarkers in obese and overweight subjects.The search process was based on the selection of publications (DB-RCT and RCT) listed in the following databases: PubMed, Web of Knowledge, Scopus, the Cochrane Library and Embase. To assess the study quality, a nine-point scoring system according to the Newcastle-Ottawa scale was used, and a high-quality study was defined by a threshold of aeyen7 points. Thirteen randomized controlled trials were included. The analysed population consisted of 1955 overweight and obese subjects. The mean age ranged from 13.6 to 71.7 years. Changes in the concentration of 25-hydroxycholecalciferol (25(OH)D), C-reactive protein (CRP), tumor necrosis factor alpha (TNF-alpha) and interleukin 6 (IL-6) were assessed. To combine individual study results, a meta-analysis was performed.The baseline levels of 25(OH)D suggested vitamin D deficiency or insufficiency in the analysed population. The vitamin D supplementation did not influence on CRP (std. mean differences -0.11; 95 % CI -0.27-0.04; p = 0.15), TNF-alpha (std. mean differences -0.13; 95 % CI -0.38-0.12; p = 0.31) and IL-6 concentrations (std. mean differences 0.1; 95 % CI -0.43-0.63; p = 0.71).This meta-analysis suggests that supplementation with vitamin D does not have a significant influence on changes in the concentration of selected inflammatory biomarkers in the obese and overweight subjects.