Genetic engineering of livestock.
Genetic engineering of livestock.
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DOI：
10.1126/science.2499927
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发表时间：
1989-06
期刊：
影响因子：
56.9
通讯作者：
V. Pursel;Carl A. Pinkert;Kurt F. Miller;D. Bolt;R. Campbell;R. Palmiter;Ralph L. Brinster;Robert E. Hammer
中科院分区：
文献类型：
--
作者：
V. Pursel;Carl A. Pinkert;Kurt F. Miller;D. Bolt;R. Campbell;R. Palmiter;Ralph L. Brinster;Robert E. Hammer
家畜基因工程可望对农业产生重大影响。然而，如果没有多代研究，就不可能准确评估转基因表达的后果。在两个转基因猪品系上进行了牛生长激素（bGH）血浆水平长期升高的有益和不利后果的系统研究。连续两代表达bGH基因的猪在日增重和饲料利用率方面均显示出显着改善，并表现出胴体组成的变化，包括皮下脂肪的显着减少。然而，bGH的长期升高通常对健康有害：猪的胃溃疡、关节炎、心脏肥大、皮炎和肾脏疾病的发生率很高。通过转基因方法生产仅表现出生长激素的有益促生长作用的猪的能力可能需要更好地控制转基因表达、不同的遗传背景或改良的饲养方案。
Genetic engineering of livestock is expected to have a major effect on the agricultural industry. However, accurate assessment of the consequences of transgene expression is impossible without multigenerational studies. A systematic study of the beneficial and adverse consequences of long-term elevations in the plasma levels of bovine growth hormone (bGH) was conducted on two lines of transgenic pigs. Two successive generations of pigs expressing the bGH gene showed significant improvements in both daily weight gain and feed efficiency and exhibited changes in carcass composition that included a marked reduction in subcutaneous fat. However, long-term elevation of bGH was generally detrimental to health: the pigs had a high incidence of gastric ulcers, arthritis, cardiomegaly, dermatitis, and renal disease. The ability to produce pigs exhibiting only the beneficial, growth-promoting effects of growth hormone by a transgenic approach may require better control of transgene expression, a different genetic background, or a modified husbandry regimen.