Association of lipoprotein-associated phospholipase A2 with coronary calcification among American and Japanese men
Association of lipoprotein-associated phospholipase A2 with coronary calcification among American and Japanese men
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DOI：
10.2188/jea.17.179
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发表时间：
2007-11-01
影响因子：
4.7
通讯作者：
Ueshima, Hirotsup
中科院分区：
文献类型：
--
作者：
El-Saed, Airnan;Sekikawa, Akira;Ueshima, Hirotsup
背景技术背景：我们以前曾报道，尽管日本男性的许多传统危险因素不太有利，但日本男性的冠状动脉钙化（CAC）患病率明显低于美国男性。为了确定脂蛋白相关磷脂酶A2（Lp-PLA 2）水平是否与两个population.METHODS之间CAC患病率的差异有关：共200名男性，年龄在40-49岁进行了检查：100名居民在阿勒格尼县，宾夕法尼亚州，美国，和100名居民在草津市，滋贺，日本。于2001- 2002年采用电子束断层扫描评价冠状动脉钙化评分（CCS），并对Lp-PLA 2水平、核磁共振（NMR）脂蛋白亚类及其他因素进行评估。美国男性的Lp-PLA 2水平高于日本男性（平均标准差分别为301.7 +/- 82.6 vs 275.9 +/- 104.7 ng/mL，p=0.06）。在所有日本男性和低密度脂蛋白（LDL）胆固醇>= 130 mg/dL的人群中，CCS>0的患病率与Lp-PLA 2水平的三分位组呈负相关（分别为p=0.08和p=0.03）。美国男性CCS>0与Lp-PLA 2三分位组之间没有任何关联（p=0.62）。虽然两个人群中的Lp-PLA 2与LDL和总胆固醇呈正相关，但美国和日本男性与NMR脂蛋白亚类的相关性不同。在调整Lp-PLA 2水平后，美国男性与日本男性相比CCS>0的高比值比并未降低。结论：Lp-PLA 2在美国和日本男性中可能具有不同的作用机制。Lp-PLA 2水平不能解释两个人群之间观察到的CAC差异。
BACKGROUND: We have previously reported that the prevalence of coronary artery calcification (CAC) was substantially lower among Japanese than American men despite a less favorable profile of many traditional risk factors in Japanese men. To determine whether lipoprotein-associated phospholipase A2 (Lp-PLA2) levels are related to the difference in the prevalence of CAC between the two populations.METHODS: A total of 200 men aged 40-49 years were examined: 100 residents in Allegheny County, Pennsylvania, United States, and 100 residents in Kusatsu City, Shiga, Japan. Coronary calcium score (CCS) was evaluated by electron-beam tomography, Lp-PLA2 levels, nuclear magnetic resonance (NMR) lipoprotein subclasses, and other factors were assessed in 2001-2002.RESULTS: Lp-PLA2 levels were higher among American than Japanese men (Mean standard deviation 301.7 +/- 82.6 versus 275.9 +/- 104.7 ng/mL, respectively, p=0.06). Among all Japanese men and those with low density lipoprotein (LDL) cholesterol >= 130 mg/dL, there was an inverse association of the prevalence of CCS>0 with the tertile groups of Lp-PLA2 levels (p=0.08 and p=0.03, respectively). American men did not have any association between CCS>0 with the tertile groups of Lp-PLA2 (p=0.62). Although Lp-PLA2 among both populations correlated positively with LDL and total cholesterol, American and Japanese men had different correlations with NMR lipoprotein subclasses. Reported high odds ratio for CCS>0 among American compared to Japanese men was not reduced after adjusting for Lp-PLA2 levels.CONCLUSION: Lp-PLA2 may have different mechanisms of action among American and Japanese men. Lp-PLA2 levels can not explain the observed CAC differences between the two populations.